Department of Neonatology, The Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Paediatric Intensive Care, The Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Acta Paediatr. 2018 Feb;107(2):270-275. doi: 10.1111/apa.14061. Epub 2017 Sep 25.
We compared neonatal deaths and end-of-life decisions in a neonatal intensive care unit (NICU) and paediatric intensive care unit (PICU) in a Dutch tertiary children's hospital.
All 235 full-term infants who died within 28 days of life between 2003 and 2013 in the NICU (n = 199) and PICU (n = 36) were retrospectively studied.
The median length of stay was three days in the NICU and seven days in the PICU (p = 0.003). The main reasons for NICU stays were asphyxia (52.8%) and congenital malformations (42.2%), and in the PICU, they were congenital malformations (97.2%) and primarily cardiac problems (83.3%, p < 0.001). The median age of death was three days in the NICU and eight days in the PICU (p < 0.001), and mortality despite full intensive care treatment was 4.0% and 25.0%, respectively. Intensive treatment was discontinued because of poor survival chances in 25.1% of NICU and 52.8% of PICU cases (p < 0.001), and care was redirected because of expected poor quality of life in 70.9% and 22.2%, respectively.
Differences between the age at death and end-of-life decisions were found between full-term infants in the NICU and PICU in the same children's hospital. Underlying disorders and doctors' attitudes may have played a role.
我们比较了荷兰一家三级儿童医院新生儿重症监护病房(NICU)和儿科重症监护病房(PICU)的新生儿死亡和生命终末期决策。
2003 年至 2013 年间,NICU(n=199)和 PICU(n=36)中所有 235 例出生后 28 天内死亡的足月婴儿均进行了回顾性研究。
NICU 的中位住院时间为 3 天,PICU 为 7 天(p=0.003)。NICU 住院的主要原因是窒息(52.8%)和先天性畸形(42.2%),而 PICU 的主要原因是先天性畸形(97.2%)和主要心脏问题(83.3%,p<0.001)。NICU 的中位死亡年龄为 3 天,PICU 为 8 天(p<0.001),尽管进行了全面的重症监护治疗,但死亡率分别为 4.0%和 25.0%。由于生存机会差,25.1%的 NICU 和 52.8%的 PICU 病例停止了强化治疗(p<0.001),由于预期生活质量差,分别有 70.9%和 22.2%的病例重新定向治疗。
在同一家儿童医院的 NICU 和 PICU 中,足月婴儿在死亡年龄和生命终末期决策方面存在差异。潜在疾病和医生的态度可能起了作用。