Li Aimei, Zhang Wei, Zhang Hao, Yi Bin
Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Aug 28;42(8):979-985. doi: 10.11817/j.issn.1672-7347.2017.08.017.
The biological effects mediated by vitamin D and vitamin D receptor (VDR) are involved in the regulation of multiple pathophysiologic processes, including calcium phosphorus metabolism, immune regulation, anti-inflammation, anti-infection and cancer prevention, etc. Autophagy is a eukaryotic cell lysosome-mediated catabolic pathway, which is classified into 3 different types: macroautophagy, microautophagy, and chaperone-mediated autophagy. Since autophagy is vital to maintain energy and metabolism in cells, autophagy dysfunction is closely associated with various pathological processes such as inflammation, infection and tumor. Studies have shown that vitamin D/VDR can affect the different stages of autophagy and regulate inflammation in autophagy. Moreover, vitamin D/VDR and autophagy play an important role in autoimmune disease, diabetes, cardiovascular disease, cancer and other inflammatory diseases.
维生素D和维生素D受体（VDR）介导的生物学效应参与多种病理生理过程的调节，包括钙磷代谢、免疫调节、抗炎、抗感染和癌症预防等。自噬是真核细胞溶酶体介导的分解代谢途径，分为3种不同类型：巨自噬、微自噬和伴侣介导的自噬。由于自噬对维持细胞内能量和代谢至关重要，自噬功能障碍与炎症、感染和肿瘤等各种病理过程密切相关。研究表明，维生素D/VDR可影响自噬的不同阶段并调节自噬中的炎症反应。此外，维生素D/VDR和自噬在自身免疫性疾病、糖尿病、心血管疾病、癌症和其他炎症性疾病中发挥重要作用。
