Department of Critical Care Medicine, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Jun 28;47(6):780-785. doi: 10.11817/j.issn.1672-7347.2022.210556.
Vitamin D plays an important role in mineral and bone homeostasis, immune responses, cardiovascular function and keratinocyte proliferation and differentiation. Vitamin D performs most of its functions by binding to vitamin D receptors (VDR), which interact with other intracellular signaling pathways to regulate bone metabolism, inflammation, immunity, cell cycle progression and apoptosis. Autophagy is a basic stress response in yeast, plants and mammals, and plays a critical role in maintaining optimal functional states at the level of cells and organs. Vitamin D/VDR plays an anti-infection role via inducing and regulating autophagy.
维生素 D 在矿物质和骨骼内稳态、免疫反应、心血管功能以及角质形成细胞增殖和分化中发挥着重要作用。维生素 D 通过与维生素 D 受体（VDR）结合来发挥其大部分功能，VDR 与其他细胞内信号通路相互作用，从而调节骨骼代谢、炎症、免疫、细胞周期进程和细胞凋亡。自噬是酵母、植物和哺乳动物中的一种基本应激反应，在维持细胞和器官的最佳功能状态方面发挥着关键作用。维生素 D/VDR 通过诱导和调节自噬发挥抗感染作用。
