Kataoka Y, Shibata K, Yamashita K, Ueki S
Brain Res. 1987 Jul 28;416(2):243-7. doi: 10.1016/0006-8993(87)90903-6.
The present study was designed to clarify the mechanism of action of benzodiazepines (BDZ) injected into the central amygdala (ACE) and mammillary body (MB). When gamma-aminobutyric acid (GABA) at doses of 30 and 70 micrograms, muscimol (0.01 and 0.03 microgram), valproate (200 micrograms), atropine (20 micrograms) and cyproheptadine (3 micrograms) were bilaterally injected into ACE, a significant and marked increase in the punished responses of conflict schedule was observed. These drugs injected into MB failed to increase the punished responses. In MB, only noradrenaline (NA, 20 micrograms) showed the anticonflict action. NA 20 micrograms also produced the anticonflict action in ACE. These results suggest that the mechanism of anticonflict action of BDZ is different in brain areas. The GABA-ergic, cholinergic, serotonergic and NA-ergic systems seem to be involved in the mechanism of anticonflict action of BDZ in ACE. While the NA-ergic system appears to be operative in MB.
本研究旨在阐明注射到中央杏仁核（ACE）和乳头体（MB）中的苯二氮䓬类药物（BDZ）的作用机制。当将剂量为30和70微克的γ-氨基丁酸（GABA）、蝇蕈醇（0.01和0.03微克）、丙戊酸盐（200微克）、阿托品（20微克）和赛庚啶（3微克）双侧注射到ACE中时，观察到冲突程序的惩罚反应显著且明显增加。将这些药物注射到MB中未能增加惩罚反应。在MB中，只有去甲肾上腺素（NA，20微克）表现出抗冲突作用。20微克的NA在ACE中也产生了抗冲突作用。这些结果表明，BDZ的抗冲突作用机制在不同脑区有所不同。GABA能、胆碱能、5-羟色胺能和NA能系统似乎参与了BDZ在ACE中的抗冲突作用机制。而NA能系统似乎在MB中起作用。
