Hensman R, Guimarães F S, Wang M, Deakin J F
University Department of Psychiatry, Withington Hospital, Manchester, UK.
Psychopharmacology (Berl). 1991;104(2):220-4. doi: 10.1007/BF02244182.
According to one formulation of the behavioural functions of 5HT, aversive conditioned stimuli mediate their behavioural and emotional effects through activation of 5HT projections from dorsal raphe nucleus to receptors of the 5HT2 family in amygdala and elsewhere. To test this theory in humans, groups of ten normal volunteers received placebo, the 5HT2 lc antagonist ritanserin (10 mg PO) and no pill. Ritanserin had no effect on skin conductance level, variability (spontaneous fluctuations) or habituation to a sequence of ten neutral tones. After a conditioning trial in which tone 11 was followed by an aversive white noise, skin conductance responses to a further ten tones were enhanced. This effect was abolished by ritanserin. The results indicate a selective involvement of 5HT2/lc receptors in modulating aversively conditioned skin conductance responses.
根据5-羟色胺（5HT）行为功能的一种表述，厌恶性条件刺激通过激活从背缝核到杏仁核及其他部位的5HT2家族受体的5HT投射来介导其行为和情感效应。为了在人类中验证这一理论，每组十名正常志愿者分别接受安慰剂、5HT2lc拮抗剂利坦色林（口服10毫克）和无药丸处理。利坦色林对皮肤电导水平、变异性（自发波动）或对十个中性音调序列的习惯化没有影响。在进行了一个条件试验后，其中第11个音调之后是厌恶性白噪声，对另外十个音调的皮肤电导反应增强。这种效应被利坦色林消除。结果表明5HT2/lc受体在调节厌恶性条件性皮肤电导反应中具有选择性作用。
