Grishkat H L, Thomas E, Yadin E
Department of Psychology, Bryn Mawr College, PA 19010.
Physiol Behav. 1993 Dec;54(6):1163-7. doi: 10.1016/0031-9384(93)90342-d.
Lesions of brain areas thought to promote anxiety do not diminish the anticonflict effects of benzodiazepines (BZDs). After initial training in the lick-suppression conflict test, eight rats received electrolytic lesions of the amygdala, dorsal raphe, locus coeruleus, and mammillary bodies. Ten others received sham lesions. Postoperative testing revealed a significant increase in punished licking at two stages after surgery in lesioned animals when compared with their own preoperative baseline levels and with the punished licking of control animals. Systemic administration of chlordiazepoxide (CDP, 2.5-10.0 mg/kg) resulted in a comparable dose-dependent increase in punished licking in both groups. These results suggest that the several structures lesioned need not be intact for CDP to have an antianxiety effect. It appears that sites of anxiolytic action are much more widely spread than currently believed and that other brain areas should be considered.
那些被认为会促进焦虑的脑区损伤并不会削弱苯二氮䓬类药物（BZDs）的抗冲突效应。在舔舐抑制冲突试验中进行初始训练后，八只大鼠接受了杏仁核、中缝背核、蓝斑和乳头体的电解损伤。另外十只大鼠接受了假手术损伤。术后测试显示，与自身术前基线水平以及对照动物的受罚舔舐相比，损伤动物在术后两个阶段的受罚舔舐显著增加。全身给予氯氮卓（CDP，2.5 - 10.0毫克/千克）导致两组中受罚舔舐都有类似的剂量依赖性增加。这些结果表明，CDP产生抗焦虑作用并不需要所损伤的几个结构保持完整。似乎抗焦虑作用的位点比目前认为的要广泛得多，应该考虑其他脑区。
