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[基于对大鼠牙髓电刺激诱导的伤害性感受行为观察的新型镇痛测试方案]

[Proposal of a new analgesia test based on the observation of nociceptive behavior induced by electric stimulation of dental pulp in the rat].

作者信息

Rajaona J, Dallel R, Chambrade S, Woda A

出版信息

C R Seances Soc Biol Fil. 1987;181(2):221-7.

PMID:2887265
Abstract

Dental pulp was electrically stimulated in the awake rat. When the stimulus intensity was progressively increased the following four nociceptive reactions successively appeared: jaw opening reflex, scratching, head rotation, vocalization. The threshold of these four reactions was observed before and after administration of three antalgic drugs. No action of the three drugs was observed for the jaw opening reflex. However each drug showed different actions on the other three reactions.

摘要

在清醒大鼠中对牙髓进行电刺激。当刺激强度逐渐增加时,依次出现以下四种伤害性反应:张口反射、搔抓、转头、发声。在给予三种镇痛药之前和之后观察这四种反应的阈值。三种药物对张口反射均无作用。然而,每种药物对其他三种反应表现出不同的作用。

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