Horowitz Mark C, Berry Ryan, Holtrup Brandon, Sebo Zachary, Nelson Tracy, Fretz Jackie A, Lindskog Dieter, Kaplan Jennifer L, Ables Gene, Rodeheffer Matthew S, Rosen Clifford J
a Department of Orthopaedics and Rehabilitation , Yale University School of Medicine , New Haven , CT , USA.
b Department of Molecular, Cell, and Developmental Biology , Yale University , New Haven , CT , USA.
Adipocyte. 2017 Jul 3;6(3):193-204. doi: 10.1080/21623945.2017.1367881. Epub 2017 Aug 24.
Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still persists today. However, we now know that marrow adipose tissue increases with age and in response to a variety of physiologic induction signals. Bone marrow adipocytes have recently been shown to influence other cell populations within the marrow and can affect whole body metabolism by the secretion of a defined set of adipokines. Recent research shows that marrow adipocytes are distinct from white, brown and beige adipocytes, indicating that the bone marrow is a distinct adipose depot. This review will highlight recent data regarding these areas and the interactions of marrow adipose tissue (MAT) with cells within and outside of the bone marrow.
一个多世纪前就在人类骨髓中发现了脂肪细胞，但直到最近，人们对它们的起源、发育、功能或与骨髓中其他细胞的相互作用仍知之甚少。这些细胞的功能意义一直未得到重视，这种观念至今仍然存在。然而，我们现在知道，骨髓脂肪组织会随着年龄增长以及对各种生理诱导信号的反应而增加。最近的研究表明，骨髓脂肪细胞会影响骨髓内的其他细胞群体，并可通过分泌一组特定的脂肪因子来影响全身代谢。最近的研究表明，骨髓脂肪细胞不同于白色、棕色和米色脂肪细胞，这表明骨髓是一个独特的脂肪储存库。本综述将重点介绍有关这些领域的最新数据，以及骨髓脂肪组织（MAT）与骨髓内外细胞的相互作用。
