Graduate Program on Pharmacology, Centre of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil; Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Food Res Int. 2017 Oct;100(Pt 1):771-779. doi: 10.1016/j.foodres.2017.08.005. Epub 2017 Aug 3.
The aim of this study was to evaluate the effect of annatto carotenoids intake associated to a single high-calorie meal (high fat and high carbohydrate) in postprandial biochemical, inflammatory and oxidative stress markers. Twelve healthy subjects (6 men, 6 women) were included in this randomised, controlled crossover study. Baseline blood samples were collected from fasting subjects that immediately received high-calorie meal without carotenoid (placebo) or containing 1.2mg/kg bixin (BIX) or 0.06mg/kg norbixin (NBIX). Blood samples were taken 60, 120 and 240min after meal intake. NBIX intake did not affect biochemical blood markers but reduced the postprandial levels of inflammatory cytokines (IL-1, IL-6 and TNF-α) and lipid oxidation 60-120min after meal. BIX only partially prevented postprandial-induced lipid oxidation. Results indicate that the intake of NBIX may be an alternative to reduce the postprandial inflammatory and oxidative stress responses to high-calorie meals.
本研究旨在评估胭脂树橙类胡萝卜素摄入对餐后生化、炎症和氧化应激标志物的影响。12 名健康受试者（6 名男性，6 名女性）被纳入这项随机对照交叉研究。空腹受试者采集基线血样，立即给予不含类胡萝卜素的高热量餐（安慰剂）或含有 1.2mg/kg 胭脂树红（BIX）或 0.06mg/kg 紫胶色酸（NBIX）。餐后 60、120 和 240 分钟采集血样。NBIX 摄入不会影响生化血液标志物，但可降低餐后炎症细胞因子（IL-1、IL-6 和 TNF-α）和脂质氧化水平，在餐后 60-120 分钟。BIX 仅部分预防餐后诱导的脂质氧化。结果表明，NBIX 的摄入可能是一种替代方法，可降低高热量餐引起的餐后炎症和氧化应激反应。
