Toledano Michel B, Huang Meng-Er
1 Laboratoire Stress Oxydant et Cancer, Institute for Integrative Biology of the Cell (I2BC) , CNRS, CEA-Saclay, Université Paris-Saclay, iBiTecS/SBIGEM, Gif-sur-Yvette, France .
2 Institut Curie, PSL Research University , CNRS UMR3348, Université Paris Sud, Université Paris-Saclay, Orsay, France .
Antioxid Redox Signal. 2017 Nov 20;27(15):1127-1129. doi: 10.1089/ars.2017.7230.
Glutathione (GSH) is the most abundant nonprotein thiol found in living organisms. Since its discovery 130 years ago, understanding its cellular functions has been the subject of intensive research. Common scientific knowledge states that GSH is a major nonenzymatic antioxidant and redox buffer. Recent approaches that consider GSH compartmentation in the eukaryotic cell challenge this traditional view and reveal novel unexpected insights into GSH metabolism and physiology. This Forum on GSH features six review articles that focus on GSH metabolism and functions in mitochondria and the endoplasmic reticulum; its connection to cellular iron homeostasis, carcinogenesis, and anticancer drug resistance; a revisited view of GSH degradation pathways; and reconsiders old concepts of its mode of action by highlighting the importance of kinetics over thermodynamic redox equilibria. Antioxid. Redox Signal. 27, 1127-1129.
谷胱甘肽（GSH）是生物体内含量最丰富的非蛋白质硫醇。自130年前被发现以来，对其细胞功能的了解一直是深入研究的主题。一般科学知识认为，GSH是一种主要的非酶抗氧化剂和氧化还原缓冲剂。最近关于真核细胞中GSH区室化的研究方法对这一传统观点提出了挑战，并揭示了对GSH代谢和生理学的新的意外见解。这个关于GSH的论坛有六篇综述文章，重点关注GSH在线粒体和内质网中的代谢和功能；它与细胞铁稳态、致癌作用和抗癌药物耐药性的联系；对GSH降解途径的重新审视；并通过强调动力学相对于热力学氧化还原平衡的重要性，重新思考其作用模式的旧概念。《抗氧化剂与氧化还原信号》，第27卷，第1127 - 1129页。
