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谷胱甘肽与铁死亡：抗癌斗争中的并肩伙伴。

GSH and Ferroptosis: Side-by-Side Partners in the Fight against Tumors.

作者信息

Jiang Yulang, Glandorff Christian, Sun Mingyu

机构信息

Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Internal Medicine in Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

出版信息

Antioxidants (Basel). 2024 Jun 6;13(6):697. doi: 10.3390/antiox13060697.

DOI:10.3390/antiox13060697
PMID:38929136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11201279/
Abstract

Glutathione (GSH), a prominent antioxidant in organisms, exhibits diverse biological functions and is crucial in safeguarding cells against oxidative harm and upholding a stable redox milieu. The metabolism of GSH is implicated in numerous diseases, particularly in the progression of malignant tumors. Consequently, therapeutic strategies targeting the regulation of GSH synthesis and metabolism to modulate GSH levels represent a promising avenue for future research. This study aimed to elucidate the intricate relationship between GSH metabolism and ferroptosis, highlighting how modulation of GSH metabolism can impact cellular susceptibility to ferroptosis and consequently influence the development of tumors and other diseases. The paper provides a comprehensive overview of the physiological functions of GSH, including its structural characteristics, physicochemical properties, sources, and metabolic pathways, as well as investigate the molecular mechanisms underlying GSH regulation of ferroptosis and potential therapeutic interventions. Unraveling the biological role of GSH holds promise for individuals afflicted with tumors.

摘要

谷胱甘肽（GSH）是生物体中一种重要的抗氧化剂，具有多种生物学功能，对保护细胞免受氧化损伤和维持稳定的氧化还原环境至关重要。GSH的代谢与多种疾病有关，尤其是在恶性肿瘤的进展过程中。因此，针对调节GSH合成和代谢以调节GSH水平的治疗策略是未来研究的一个有前景的途径。本研究旨在阐明GSH代谢与铁死亡之间的复杂关系，强调GSH代谢的调节如何影响细胞对铁死亡的易感性，进而影响肿瘤和其他疾病的发展。本文全面概述了GSH的生理功能，包括其结构特征、理化性质、来源和代谢途径，还研究了GSH调节铁死亡的分子机制和潜在的治疗干预措施。揭示GSH的生物学作用对肿瘤患者有一定的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/f868bfac028c/antioxidants-13-00697-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/e685a50965fc/antioxidants-13-00697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/9ed21ce94e84/antioxidants-13-00697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/4ebe8c2267dc/antioxidants-13-00697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/24782911c1ee/antioxidants-13-00697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/2b051aa632d4/antioxidants-13-00697-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/f868bfac028c/antioxidants-13-00697-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/e685a50965fc/antioxidants-13-00697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/9ed21ce94e84/antioxidants-13-00697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/4ebe8c2267dc/antioxidants-13-00697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/24782911c1ee/antioxidants-13-00697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/2b051aa632d4/antioxidants-13-00697-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2644/11201279/f868bfac028c/antioxidants-13-00697-g006.jpg

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J Am Chem Soc. 2024 Jan 10;146(1):330-341. doi: 10.1021/jacs.3c09202. Epub 2023 Dec 19.
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SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation.SMURF2 通过促进 GSTP1 降解以 GPX4 非依赖的方式使癌细胞易于发生铁死亡。
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J Nanobiotechnology. 2025 Jul 9;23(1):497. doi: 10.1186/s12951-025-03569-7.
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