健康绝经后女性的肥胖与重复元件DNA甲基化之间的关联。
Associations between adiposity and repetitive element DNA methylation in healthy postmenopausal women.
作者信息
Boyne Devon J, Friedenreich Christine M, McIntyre John B, Courneya Kerry S, King Will D
机构信息
Department of Cancer Epidemiology & Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, AB, Canada.
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
出版信息
Epigenomics. 2017 Oct;9(10):1267-1277. doi: 10.2217/epi-2017-0047. Epub 2017 Sep 6.
AIM
To describe the association between adiposity and repetitive element DNA methylation in healthy postmenopausal women.
PATIENTS & METHODS: A cross-sectional study was conducted using baseline information from 289 women who participated in the Alberta Physical Activity and Breast Cancer Prevention trial.
RESULTS
After adjusting for important confounders, long interspersed nuclear element-1 methylation was positively associated with intra-abdominal fat area (p = 0.03), body fat percent (p = 0.048), fat mass (p = 0.01), waist circumference (p = 0.03), hip circumference (p = 0.001), BMI (p = 0.03), current weight (p = 0.002), weight at age 20 (p = 0.02) and adulthood weight gain (p = 0.03). No significant associations were found between any of the adiposity measures and Alu methylation.
CONCLUSION
Current and historical adiposity measures are positively associated with long interspersed nuclear element-1 methylation in healthy postmenopausal women.
目的
描述健康绝经后女性肥胖与重复元件DNA甲基化之间的关联。
患者与方法
采用参与艾伯塔省体育活动与乳腺癌预防试验的289名女性的基线信息进行横断面研究。
结果
在对重要混杂因素进行调整后，长散在核元件-1甲基化与腹内脂肪面积呈正相关（p = 0.03）、体脂百分比呈正相关（p = 0.048）、脂肪量呈正相关（p = 0.01）、腰围呈正相关（p = 0.03）、臀围呈正相关（p = 0.001）、体重指数呈正相关（p = 0.03）、当前体重呈正相关（p = 0.002）、20岁时体重呈正相关（p = 0.02）以及成年期体重增加呈正相关（p = 0.03）。未发现任何肥胖指标与Alu甲基化之间存在显著关联。
结论
在健康绝经后女性中，当前和既往的肥胖指标与长散在核元件-1甲基化呈正相关。
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