Aging and Muscle Metabolism Laboratory, Department of Physiology, School of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Magnetic Resonance Spectroscopy and Methodology, Department of Clinical Research, University of Bern, Bern, Switzerland.
Clin Endocrinol (Oxf). 2019 Mar;90(3):433-439. doi: 10.1111/cen.13921. Epub 2019 Jan 9.
Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women.
Observational, cross-sectional study of healthy, community dwelling postmenopausal women.
Postmenopausal women (60-80 years old) were included in this study. Overall body composition was evaluated by dual-energy X-ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography-tandem mass spectrometry.
Thirty-five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05).
Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.
关于老年女性血清雄激素与脂肪组织之间关系的研究结果并不一致。我们旨在使用最先进的技术来阐明这种关系，以评估绝经后老年女性体脂分布与血浆睾丸酮（T）水平之间的关联。
对健康的社区居住的绝经后妇女进行观察性、横断面研究。
本研究纳入了绝经后妇女（60-80 岁）。通过双能 X 射线吸收法评估总体身体成分。通过磁共振成像测量腹部和大腿脂肪沉积。通过液相色谱-串联质谱法分析循环 T 浓度。
35 名女性（66.6±0.8 岁）参与了这项研究。T 水平与包括体重（ρ=0.39）、BMI（ρ=0.43）和腰围（ρ=0.39）在内的肥胖临床替代指标呈正相关（均 P<0.05）。脂肪量和体脂百分比与 T 水平相关（ρ=0.42 和 0.38，均 P<0.05）。T 与整体和腹部浅表脂肪相关（ρ=0.34 和 0.37，均 P<0.05），但与内脏脂肪组织无关。T 与大腿脂肪量增加呈正相关（ρ=0.49，P<0.05），无论在浅层还是深层脂肪中均如此（ρ=0.50 和 0.35，均 P<0.05）。
我们的结果表明，循环 T 水平较高的绝经后妇女具有更高的局部和整体身体肥胖。这些发现强调了血清雄激素水平与肥胖之间关系的性别二态性。
