Shigeta H, Tasaki N, Kitazumi S, Kitagawa Y, Nakano K, Kanatsuna T, Kondo M
Endocrinol Jpn. 1987 Apr;34(2):309-12. doi: 10.1507/endocrj1954.34.309.
The study was conducted to examine the effect of somatostatin on activated renin-angiotensin-aldosterone system in a case of Bartter's syndrome. After 60 minutes of 500 micrograms of somatostatin infusion, the plasma aldosterone concentration was reduced from the basal level of 250 pg/ml to 140 pg/ml, whereas plasma renin activity remained at the basal level. This result suggests that somatostatin may specifically inhibit aldosterone secretion in Bartter's syndrome and the agent can be applied to a treatment of this syndrome.
本研究旨在探讨生长抑素对Bartter综合征患者激活的肾素-血管紧张素-醛固酮系统的影响。在输注500微克生长抑素60分钟后，血浆醛固酮浓度从基础水平的250皮克/毫升降至140皮克/毫升，而血浆肾素活性维持在基础水平。该结果表明生长抑素可能特异性抑制Bartter综合征中的醛固酮分泌，且该药物可用于治疗此综合征。
