Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China.
Sci Rep. 2017 Sep 5;7(1):10464. doi: 10.1038/s41598-017-10676-5.
Not all patients with major depressive disorder respond to adequate pharmacological therapy. Psychoradiological studies have reported that antidepressant responders and nonresponders show different alterations in brain grey matter, but the findings are inconsistent. The present study reports a meta-analysis of voxel-based morphometric studies of patients with major depressive disorder, both antidepressant responders and nonresponders, using the anisotropic effect size version of Seed-based D Mapping to identify brain regions correlated to clinical response. A systematic search was conducted up to June 2016 to identify studies focussing on antidepressant response. In responders across 9 datasets grey matter volume (GMV) was significantly higher in the left inferior frontal gyrus and insula, while GMV was significantly lower in the bilateral anterior cingulate cortex (ACC) and the right superior frontal gyrus (SFG). In nonresponders across 5 datasets GMV was significantly lower in the bilateral ACC, median cingulate cortex (MCC) and right SFG. Conjunction analysis confirmed significant differences in the bilateral ACC and right SFG, where GMV was significantly lower in nonresponders but higher in responders. The current study adds to psychoradiology, an evolving subspecialty of radiology mainly for psychiatry and clinical psychology.
并非所有重度抑郁症患者对充分的药物治疗都有反应。心理放射学研究报告称，抗抑郁药反应者和无反应者的大脑灰质显示出不同的改变，但结果不一致。本研究对使用基于种子的 D 映射的各向异性效应大小版本对有抗抑郁反应的患者（包括抗抑郁药反应者和无反应者）进行了基于体素的形态计量学研究的荟萃分析，以确定与临床反应相关的大脑区域。截至 2016 年 6 月进行了系统搜索，以确定专注于抗抑郁反应的研究。在 9 个数据集的反应者中，左侧额下回和脑岛的灰质体积（GMV）显著较高，而双侧前扣带皮质（ACC）和右侧额上回（SFG）的 GMV 显著较低。在 5 个数据集的无反应者中，双侧 ACC、中央扣带皮质（MCC）和右侧 SFG 的 GMV 显著较低。连接分析证实双侧 ACC 和右侧 SFG 存在显著差异，无反应者的 GMV 显著较低，而反应者的 GMV 较高。本研究增加了心理放射学，这是放射学的一个不断发展的亚专业，主要用于精神病学和临床心理学。
