Hallmaier-Wacker Luisa K, Munster Vincent J, Knauf Sascha
Work Group Neglected Tropical Diseases, Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Göttingen 37077, Germany.
Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Göttingen 37077, Germany.
Emerg Microbes Infect. 2017 Sep 6;6(9):e79. doi: 10.1038/emi.2017.65.
Central to the One Health approach and any disease eradication program is the question of whether a pathogen has a non-human reservoir. Despite well-established conceptual frameworks that define a reservoir of infection, empirical characterization of reservoirs often remains controversial, challenging and sometimes misleading. What is essentially missing are applicable requirements that standardize the use of the term 'reservoir of infection' across multiple disciplines. We propose an empirical framework, considering maintenance and feasible transmission of a pathogen, to standardize the acceptance of a disease reservoir across multiple disciplines. We demonstrate the intended use of these requirements by applying them to different diseases that are known to infect both humans and animals.
“同一健康”方法及任何疾病根除计划的核心问题是病原体是否存在非人类宿主。尽管已有明确的概念框架来定义感染宿主，但对宿主的实证特征描述往往仍存在争议、具有挑战性，有时甚至会产生误导。本质上缺失的是跨多学科规范“感染宿主”一词使用的适用要求。我们提出一个实证框架，考虑病原体的维持和可行传播，以跨多学科规范对疾病宿主的认定。我们通过将这些要求应用于已知感染人类和动物的不同疾病来展示其预期用途。
