Poddar N, Ramlal R, Ravulapati S, Devlin S M, Gadani S, Vidal C I, Cao D, Befeler A S, Lai J
Division of Hematology Oncology.
Department of Internal Medicine.
Curr Oncol. 2017 Aug;24(4):e333-e336. doi: 10.3747/co.24.3494. Epub 2017 Aug 31.
Hepatocellular carcinoma (hcc) arising from a hepatic adenoma is a rare phenomenon accounting for fewer than 5% of hcc cases; it seldom recurs after resection of the primary tumour. We report a case of extrahepatic metastasis of hcc arising from a hepatic adenoma that presented as a solitary sternal metastasis without any evidence of intrahepatic recurrence. Our patient was initially treated with radiation therapy and bland embolization, without response. Subsequently, the patient developed progressive disease while taking sorafenib. He later received chemotherapy with docetaxel and gemcitabine, with the development of multiple pulmonary and splenic nodules. However, he remained free of intrahepatic recurrence. To the best of our knowledge, this is the first case of extrahepatic metastasis of hcc arising from a hepatic adenoma without evidence of intrahepatic recurrence.
源自肝腺瘤的肝细胞癌（HCC）是一种罕见现象，占HCC病例不到5%；原发性肿瘤切除后很少复发。我们报告一例源自肝腺瘤的HCC肝外转移病例，表现为孤立性胸骨转移，无肝内复发证据。我们的患者最初接受放射治疗和单纯栓塞治疗，无反应。随后，患者在服用索拉非尼时病情进展。他后来接受多西他赛和吉西他滨化疗，出现多个肺和脾结节。然而，他仍无肝内复发。据我们所知，这是首例源自肝腺瘤的HCC肝外转移且无肝内复发证据的病例。
