School of Public Health, The University of Queensland, Herston, Queensland, Australia.
Obes Rev. 2017 Nov;18(11):1364-1373. doi: 10.1111/obr.12591. Epub 2017 Sep 6.
Obesity and weight gain have been associated with poor disease-specific and health-related outcomes in women with breast cancer.
This review aimed to evaluate the effectiveness of weight gain prevention interventions among women with breast cancer.
Completed and ongoing trials evaluating a behaviourally based dietary intervention with or without physical activity and with a focus on weight gain prevention during treatment for breast cancer were reviewed. Weight change and body composition data were extracted. Within-group weight change of ±1 kg and between-group (intervention versus control) weight difference of ≥2 kg were defined as successful weight gain prevention.
Five completed trials (seven intervention arms) and five ongoing trials were identified. Completed trials exclusively recruited premenopausal or premenopausal and postmenopausal women. Within-group weight gain was prevented in two intervention arms, two arms achieved weight loss and three arms reported weight gain. Of the five comparisons with control groups, two reported significant differences in weight change between groups. Ongoing trials will provide further evidence on longer-term outcomes, cost-effectiveness and blood markers.
This small but growing number of studies provides preliminary and promising evidence that weight gain can be prevented in women with breast cancer undergoing chemotherapy.
肥胖和体重增加与乳腺癌女性的疾病特异性和健康相关结局较差有关。
本综述旨在评估乳腺癌女性中预防体重增加干预的有效性。
对已完成和正在进行的试验进行了评估，这些试验评估了一种基于行为的饮食干预措施，是否结合了身体活动，以及在乳腺癌治疗期间侧重于预防体重增加。提取体重变化和身体成分数据。体重增加或减少±1kg 和干预组与对照组之间的体重差异≥2kg 被定义为成功预防体重增加。
确定了五项已完成的试验（七个干预组）和五项正在进行的试验。已完成的试验专门招募了绝经前或绝经前和绝经后女性。两个干预组预防了体重增加，两个组实现了体重减轻，三个组报告了体重增加。在与对照组的五项比较中，有两项报告了组间体重变化的显著差异。正在进行的试验将提供关于长期结果、成本效益和血液标志物的进一步证据。
尽管数量较少，但这一系列研究提供了初步的、有前景的证据，表明接受化疗的乳腺癌女性可以预防体重增加。
