a Drug Delivery Research Group, School of Science , Auckland University of Technology , Auckland , New Zealand.
b Buchanan Ocular Therapeutics Unit, Department of Ophthalmology , New Zealand National Eye Centre, University of Auckland , Auckland , New Zealand.
Pharm Dev Technol. 2018 Mar;23(3):255-260. doi: 10.1080/10837450.2017.1377232. Epub 2017 Sep 21.
Corneal blindness can occur due to improper healing of the corneal tissues after induced injury or abrasion which can be accidental, pathogenic, or after corneal surgery. Abnormal regulation of the healing mechanisms can lead to corneal opacity. Reducing inflammation and promoting epithelial wound healing are crucial for scar-free corneal recovery without eyesight complications. Current approaches for corneal wound healing involve amniotic membrane (AM) bandages, bandage contact lenses (BCL), and collagen shields in conjunction with frequent administration of therapeutic eye drops. The problem with eye drops is poor bioavailability and patient incompliance that might lead to corneal wound healing complications and poor clinical outcomes. Various methods have been proposed for loading drugs into medicated bandage lenses. There are advantages and limitations associated with each technique regarding the ease of manufacture, drug loading, release kinetics, and suitability with various therapeutics and hydrogel types. There is still, however, no drug-eluting corneal bandage on the market despite the need for such a convenient and cost-efficient strategy for corneal wound healing. This review will highlight materials and therapeutics that can be used in medicated ocular bandages and various ways of incorporating drugs, while discussing the limitations and challenges associated with bringing medicated ocular bandages in the market.
角膜盲症可因诱导性损伤或擦伤后角膜组织愈合不当而发生，其原因可能是意外、疾病或角膜手术后。愈合机制的异常调节可导致角膜混浊。减少炎症和促进上皮伤口愈合对于无视力并发症的无痕角膜恢复至关重要。目前，角膜伤口愈合的方法包括羊膜（AM）绷带、绷带接触镜（BCL）和胶原盾，同时频繁使用治疗性眼药水。眼药水的问题是生物利用度差和患者不依从，这可能导致角膜伤口愈合并发症和不良的临床结果。已经提出了各种将药物载入药物绷带镜片的方法。每种技术在制造、药物负载、释放动力学以及与各种治疗药物和水凝胶类型的适用性方面都有其优缺点和局限性。然而，尽管角膜伤口愈合需要这种方便且具有成本效益的策略，但市场上仍然没有洗脱药物的角膜绷带。本综述将重点介绍可用于药物绷带眼的材料和治疗药物，以及各种药物掺入方法，同时讨论将药物绷带眼引入市场所面临的限制和挑战。
