Department of Chemistry, Koc University, Istanbul 34450, Turkey.
Department of Biology, Uludag University, Bursa 16059, Turkey.
Nanomedicine (Lond). 2017 Oct;12(19):2319-2333. doi: 10.2217/nnm-2017-0180. Epub 2017 Sep 6.
We aim to develop folic acid (FA)-conjugated cationic AgS near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region.
MATERIALS & METHODS: Cationic AgS NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells.
Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated AgS NIRQDs.
These AgS NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.
我们旨在开发叶酸（FA）修饰的阳离子 AgS 近红外量子点（NIRQDs），用于将阿霉素（DOX）选择性递送至叶酸受体（FR）阳性癌细胞，以实现增强的药物疗效和在近红外区域的光学跟踪。
通过 PEG 桥将阳离子 AgS NIRQDs 与 FA 缀合，并装载 DOX。在 FR 阳性人宫颈癌细胞和 FR 阴性 A549 细胞上进行了体外研究。
与负载 DOX 的未修饰 AgS NIRQDs 相比，负载 DOX 的 FA 修饰的 AgS NIRQDs 被人宫颈癌细胞摄取显著增加，并且治疗效果更好，同时具有强烈的细胞内光学信号。
这些 AgS NIRQDs 是具有前景的治疗诊断纳米颗粒，可用于受体介导的 DOX 递药，具有增强的药物疗效和光学成像。
