叶酸偶联阳离子 AgS 量子点用于 HeLa 细胞的光学成像和阿霉素的选择性递送。
Folic acid-conjugated cationic AgS quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells.
机构信息
Department of Chemistry, Koc University, Istanbul 34450, Turkey.
Department of Biology, Uludag University, Bursa 16059, Turkey.
出版信息
Nanomedicine (Lond). 2017 Oct;12(19):2319-2333. doi: 10.2217/nnm-2017-0180. Epub 2017 Sep 6.
AIM
We aim to develop folic acid (FA)-conjugated cationic AgS near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region.
MATERIALS & METHODS: Cationic AgS NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells.
RESULTS
Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated AgS NIRQDs.
CONCLUSION
These AgS NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.
目的
我们旨在开发叶酸（FA）修饰的阳离子 AgS 近红外量子点（NIRQDs），用于将阿霉素（DOX）选择性递送至叶酸受体（FR）阳性癌细胞，以实现增强的药物疗效和在近红外区域的光学跟踪。
材料与方法
通过 PEG 桥将阳离子 AgS NIRQDs 与 FA 缀合，并装载 DOX。在 FR 阳性人宫颈癌细胞和 FR 阴性 A549 细胞上进行了体外研究。
结果
与负载 DOX 的未修饰 AgS NIRQDs 相比，负载 DOX 的 FA 修饰的 AgS NIRQDs 被人宫颈癌细胞摄取显著增加，并且治疗效果更好，同时具有强烈的细胞内光学信号。
结论
这些 AgS NIRQDs 是具有前景的治疗诊断纳米颗粒，可用于受体介导的 DOX 递药，具有增强的药物疗效和光学成像。
Zotero 插件