Androutsou Maria-Eleni, Tapeinou Anthi, Vlamis-Gardikas Alexios, Tselios Theodore
Vianex S.A., Tatoiou Str., 18th km Athens-Lamia National Road 14671, Nea Erythrea, Greece.
Department of Chemistry, University of Patras, GR-26504, Rion, Greece.
Med Chem. 2018 Feb 6;14(2):120-128. doi: 10.2174/1573406413666170906123204.
Myelin oligodendrocyte glycoprotein (MOG) is located on the external surface of myelin, a membranous component of the central nervous system (CNS) that forms the insulating lipid layer around neurons. The major MOG splicing variant (a1 transcript) encodes a transmembrane protein with an extracellular domain of an Ig variable (IgV) fold. MOG IgV domains from the same or different cells dimerize and contribute to the organization and maintenance of the myelin sheath in neurons. The encepalitogenic T cells recognize MOG and its immunodominant epitopes (epitopes 1-22, 35-55 and 92-106 located at the dimer interface) as foreign antigens and cause the destruction of myelin (demyelination) leading to the clinical condition known as multiple sclerosis (MS). Recognition of the antigen takes place in the context of the trimolecular complex formed by HLA, MOGpeptides and TCR.
Understanding the role of MOG in MS.
METHOD/RESULTS: We have reviewed herein, the genomic organization of the human MOG gene, the structural characteristics of the MOG protein, the involvement of MOG in MS and clinical studies for the treatment of MS based on MOG peptide analogues.
Conjugates of antigenic MOG peptides to mannan and combinations of antigenic MOG and other peptides chemically linked to cells of the immune system may modify the immune response, alleviating in some cases the symptoms of MS.
髓鞘少突胶质细胞糖蛋白（MOG）位于髓鞘的外表面，髓鞘是中枢神经系统（CNS）的一种膜性成分，围绕神经元形成绝缘脂质层。主要的MOG剪接变体（a1转录本）编码一种跨膜蛋白，其胞外结构域具有免疫球蛋白可变（IgV）折叠。来自相同或不同细胞的MOG IgV结构域二聚化，并有助于神经元中髓鞘的组织和维持。致脑炎性T细胞将MOG及其免疫显性表位（位于二聚体界面的表位1 - 22、35 - 55和92 - 106）识别为外来抗原，并导致髓鞘破坏（脱髓鞘），从而引发称为多发性硬化症（MS）的临床病症。抗原的识别发生在由HLA、MOG肽和TCR形成的三分子复合物的背景下。
了解MOG在MS中的作用。
方法/结果：我们在此回顾了人类MOG基因的基因组组织、MOG蛋白的结构特征、MOG在MS中的作用以及基于MOG肽类似物治疗MS的临床研究。
抗原性MOG肽与甘露聚糖的缀合物以及抗原性MOG与其他化学连接到免疫系统细胞的肽的组合可能会改变免疫反应，在某些情况下减轻MS的症状。
