Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics (SIIA), Chengdu University , Chengdu, Sichuan 610052, People's Republic of China.
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Materials Science and Engineering, City University of Hong Kong , Hong Kong SAR.
ACS Appl Mater Interfaces. 2017 Sep 27;9(38):32990-33000. doi: 10.1021/acsami.7b10064. Epub 2017 Sep 18.
Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8-poly(acrylic acid sodium salt) (ZIF-8-PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8-PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal-organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.
采用 PAAS 纳米球作为软模板，制备了纳米尺寸可控且表面可修饰的沸石咪唑酯骨架-8-聚（丙烯酸钠）（ZIF-8-PAAS）纳米复合材料。这些 ZIF-8-PAAS 纳米复合材料具有 30 至 200nm 的不同粒径，并表现出不同的结晶度和 pH 敏感性。这些纳米复合材料可用作载体来输送阿霉素进行抗癌治疗，在细胞系和小鼠模型中的测试结果表明，其药物治疗效果大大增强。包括肿瘤和主要器官的苏木精和伊红染色分析、血液分析和血液化学分析在内的系统毒性研究表明，该纳米复合材料具有很高的生物相容性。这项工作为在纳米尺度上实现具有尺寸可调性和灵活表面修饰的金属有机骨架（MOFs）纳米复合材料提供了一种策略，可应用于各种领域。
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