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Metal-Organic Frameworks and Their Composites Towards Biomedical Applications.

作者信息

Ma Yana, Qu Xianglong, Liu Cui, Xu Qiuran, Tu Kangsheng

机构信息

School of Basic Medical Sciences, Xi'an Key Laboratory of Immune Related Diseases, Xi'an Jiaotong University, Xi'an, China.

Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, China.

出版信息

Front Mol Biosci. 2021 Dec 21;8:805228. doi: 10.3389/fmolb.2021.805228. eCollection 2021.

DOI:10.3389/fmolb.2021.805228
PMID:34993235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8724581/
Abstract

Owing to their unique features, including high cargo loading, biodegradability, and tailorability, metal-organic frameworks (MOFs) and their composites have attracted increasing attention in various fields. In this review, application strategies of MOFs and their composites in nanomedicine with emphasis on their functions are presented, from drug delivery, therapeutic agents for different diseases, and imaging contrast agents to sensor nanoreactors. Applications of MOF derivatives in nanomedicine are also introduced. Besides, we summarize different functionalities related to MOFs, which include targeting strategy, biomimetic modification, responsive moieties, and other functional decorations. Finally, challenges and prospects are highlighted about MOFs in future applications.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/31524ad376b5/fmolb-08-805228-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/77a4bc7a7f57/fmolb-08-805228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/2c8d92e3ecd8/fmolb-08-805228-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/2cb413d64f65/fmolb-08-805228-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/23103680dbcf/fmolb-08-805228-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/180eb8af8fb0/fmolb-08-805228-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/3c98114097d8/fmolb-08-805228-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/049dcf30cf3f/fmolb-08-805228-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/58b9d1788090/fmolb-08-805228-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/9b4f2e7fb18b/fmolb-08-805228-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/95dfcedbc874/fmolb-08-805228-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/5694d73feb94/fmolb-08-805228-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/196fa2348a27/fmolb-08-805228-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/1ad949ed91d2/fmolb-08-805228-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/31524ad376b5/fmolb-08-805228-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/77a4bc7a7f57/fmolb-08-805228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/2c8d92e3ecd8/fmolb-08-805228-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/2cb413d64f65/fmolb-08-805228-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/23103680dbcf/fmolb-08-805228-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/180eb8af8fb0/fmolb-08-805228-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/3c98114097d8/fmolb-08-805228-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/049dcf30cf3f/fmolb-08-805228-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/58b9d1788090/fmolb-08-805228-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/9b4f2e7fb18b/fmolb-08-805228-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/95dfcedbc874/fmolb-08-805228-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/5694d73feb94/fmolb-08-805228-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/196fa2348a27/fmolb-08-805228-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/1ad949ed91d2/fmolb-08-805228-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38d0/8724581/31524ad376b5/fmolb-08-805228-g014.jpg

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本文引用的文献

[1]
Conferring Ti-Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy.

Adv Mater. 2021-5

[2]
Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine.

Front Bioeng Biotechnol. 2021-3-11

[3]
A Cationic Metal-Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management.

Nano Lett. 2021-3-24

[4]
Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy.

Int J Nanomedicine. 2021

[5]
Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH/chitosan composite membrane for antibacterial properties.

Biomater Sci. 2021-4-7

[6]
MOFs-Derived Fe-N Codoped Carbon Nanoparticles as O-Evolving Reactor and ROS Generator for CDT/PDT/PTT Synergistic Treatment of Tumors.

Bioconjug Chem. 2021-2-17

[7]
Sustained and targeted delivery of checkpoint inhibitors by metal-organic frameworks for cancer immunotherapy.

Sci Adv. 2021-1

[8]
Multienzyme-Mimic Ultrafine Alloyed Nanoparticles in Metal Organic Frameworks for Enhanced Chemodynamic Therapy.

Small. 2021-2

[9]
Nano-MOFs as targeted drug delivery agents to combat antibiotic-resistant bacterial infections.

R Soc Open Sci. 2020-12-2

[10]
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors.

Theranostics. 2021

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