用于生理pH响应性药物递送的锌（II）金属有机框架纳米载体的最新进展。
Recent developments on zinc(ii) metal-organic framework nanocarriers for physiological pH-responsive drug delivery.
作者信息
Liu Weicong, Pan Ying, Xiao Weiwei, Xu Hongjia, Liu Dong, Ren Fei, Peng Xinsheng, Liu Jianqiang
机构信息
Guangdong Key Laboratory for Research and Development of Natural Drugs, Dongguan Key Laboratory of Drug Design and Formulation Technology , Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University and School of Pharmacy , Guangdong Medical University , Dongguan , 523808 , P. R. China . Email:
Biosafety Level-3 Laboratory , Guangdong Provincial Key Laboratory of Tropical Disease Research , School of Public Health , Southern Medical University , Guangdong , Guangzhou 510515 , China.
出版信息
Medchemcomm. 2019 Oct 17;10(12):2038-2051. doi: 10.1039/c9md00400a. eCollection 2019 Dec 1.
The high storage capacities and excellent biocompatibilities of zinc(ii) metal-organic frameworks (Zn-MOFs) have made them outstanding candidates as drug delivery carriers. Recent studies on the pH-responsive processes based on carrier-drug interactions have proven them to be the most efficient and effective way to control the release profiles of drugs. To satisfy the ever-growing demand in cancer therapy, great efforts are being devoted to the development of methods to precisely control drug release and achieve targeted use of an active substance at the right time and place. In this review article, we discuss the diverse stimuli based on Zn-MOFs carriers that have been achieved upon external activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints. Also, the perspectives and future challenges in this type of carrier system are discussed.
锌（II）金属有机框架材料（Zn-MOFs）具有高存储容量和出色的生物相容性，使其成为药物递送载体的杰出候选者。最近基于载体-药物相互作用的pH响应过程的研究证明，它们是控制药物释放曲线的最有效方法。为了满足癌症治疗中不断增长的需求，人们正在大力开发精确控制药物释放并在正确的时间和地点实现活性物质靶向使用的方法。在这篇综述文章中，我们从单一pH刺激响应或/和多重pH刺激响应的外部激活角度，讨论了基于Zn-MOFs载体实现的多种刺激。此外，还讨论了这种载体系统的前景和未来挑战。
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