Lira S M, Canabrava N V, Benjamin S R, Silva J Y G, Viana D A, Lima C L S, Paredes P F M, Marques M M M, Pereira E O, Queiroz E A M, Guedes M I F
Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.
Laboratório de Patologia Clínica Pathovet, Fortaleza, CE, Brasil.
Braz J Med Biol Res. 2017 Aug 31;50(10):e6361. doi: 10.1590/1414-431X20176361.
Diabetes mellitus is one of the most common chronic degenerative diseases, and it is estimated to increase worldwide to around 415 million and to impact 642 million in 2040. Research shows that some plants are sources of bioactive compounds against diabetes. Thus, the objective of this work was to evaluate the oral toxicity and the hypoglycemic effect of the aqueous extract of the leaves of Cnidoscolus quercifolius Pohl. Diabetes was induced in Swiss mice with streptozotocin and the mice were treated with an aqueous extract of C. quercifolius leaves for a period of 30 days. Phytochemical analysis showed that the extract was rich in flavonoids, catechins and triterpenoid, which did not show any mortality and behavioral alterations in mice treated with 200, 1000, and 2000 mg/kg body weight of the extract for 14 days. Histopathological analysis of organs (kidney, pancreas, liver) from mice treated with the 2000 mg/kg extract revealed no architectural change. In the present study, we found a 29% reduction in glucose levels in animals receiving 200 mg/kg body weight. These results are very promising because they showed that C. quercifolius had a hypoglycemic effect and did not present oral toxicity, thus being a new source of compounds for the control of diabetes.
糖尿病是最常见的慢性退行性疾病之一，据估计全球糖尿病患者数量将增至约4.15亿，到2040年将影响6.42亿人。研究表明，一些植物是抗糖尿病生物活性化合物的来源。因此，本研究的目的是评估栎叶大戟叶片水提取物的口服毒性和降血糖作用。用链脲佐菌素诱导瑞士小鼠患糖尿病，并用栎叶大戟叶片水提取物对小鼠进行为期30天的治疗。植物化学分析表明，该提取物富含黄酮类化合物、儿茶素和三萜类化合物，用200、1000和2000mg/kg体重的提取物处理小鼠14天，未观察到任何死亡和行为改变。对用2000mg/kg提取物处理的小鼠的器官（肾脏、胰腺、肝脏）进行组织病理学分析，未发现结构变化。在本研究中，我们发现接受200mg/kg体重提取物的动物血糖水平降低了29%。这些结果非常有前景，因为它们表明栎叶大戟具有降血糖作用且无口服毒性，因此是控制糖尿病的新化合物来源。
