Pinto Maria E A, Araújo Sthéfane G, Morais Marcela I, Sá Nívea P, Lima Caroline M, Rosa Carlos A, Siqueira Ezequias P, Johann Susana, Lima Luciana A R S
Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del Rei, Rua Sebastião Gonçalves Coelho, 400, Chanadour, 35501-296 Divinópolis, MG, Brazil.
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
An Acad Bras Cienc. 2017 Jul-Sep;89(3):1671-1681. doi: 10.1590/0001-3765201720160908. Epub 2017 Aug 31.
Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.
脂肪酸甲酯（FAMEs）从大豆、玉米和向日葵植物油中获得。当前研究主要聚焦于评估FAMEs对副球孢子菌属的抗真菌活性，以及测试这些化合物与商用抗真菌药物的相互作用及其抗氧化潜力。FAMEs呈现出较小的半数抑制浓度（IC50）值（1.86 - 9.42微克/毫升）。所有测试的三种FAMEs均对副球孢子菌属分离株显示出抗真菌活性，其最低抑菌浓度（MIC）值范围为15.6 - 500微克/毫升。向日葵FAMEs表现出的抗真菌活性还扩展到其他属，对光滑念珠菌和克柔念珠菌的MIC为15.6微克/毫升，对近平滑念珠菌的MIC为31.2微克/毫升。FAMEs与伊曲康唑表现出协同效应。FAMEs对副球孢子菌属分离株的抗真菌活性可能归因于亚油酸甲酯的存在，它是所有三种FAMEs中的主要化合物。所得结果表明FAMEs作为抗真菌和抗氧化活性来源的潜力。
