肝脏作为产热的中心。
The Liver as a Hub in Thermogenesis.
机构信息
Medicine and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Cell Metab. 2017 Sep 5;26(3):454-455. doi: 10.1016/j.cmet.2017.08.018.
PMID:28877451
Abstract
Manipulating thermogenesis could increase energy expenditure and improve metabolism. Brown fat is a major site of nonshivering thermogenesis, but other tissues, notably muscle and liver, can contribute to cold adaptation. In this issue, Simcox et al. (2017) demonstrate in cold-exposed mice that liver-generated acylcarnitines are required to fuel thermogenesis.
摘要
调控产热作用可以增加能量消耗并改善代谢。棕色脂肪是不颤抖产热的主要部位，但其他组织，特别是肌肉和肝脏，也有助于适应寒冷。在本期杂志中，Simcox 等人（2017）证明，在暴露于寒冷中的小鼠中，肝脏产生的酰基辅酶 A 是产热作用的燃料所必需的。
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