Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
The National Health Insurance Service, Wonju, 25234, Republic of Korea.
Orphanet J Rare Dis. 2017 Sep 6;12(1):152. doi: 10.1186/s13023-017-0705-2.
The aim of this study was to assess in amyloidosis prevalence in Korea between 2006 and 2015.
Primary diagnoses related to amyloidosis, regardless of subtype, were collected from the Korean National Health Insurance Service from 2006 through 2015.
Overall, the age-standardized prevalence of amyloidosis was 0.93 (95% confidence interval (CI) 0.81, 1.04) persons per 100,000 persons in 2006 and 1.91 (95% CI 1.78, 2.05) persons per 100,000 persons in 2015. This included an increase from 0.43 (95% CI 0.35, 0.51) to 1.04 (95% CI 0.94, 1.14) persons per 100,000 persons in men and from 0.49 (95% CI 0.40, 0.57) to 0.87 (95% CI 0.77, 0.96) persons per 100,000 persons in women. In particular, the age-standardized prevalence of amyloidosis showed a greater increase in patients aged 65 years or older and in patients aged 45-64 years than in patients aged 20-44 years, for both men and women.
The overall age-standardized prevalence of amyloidosis was approximately 2 persons per 100,000 persons in 2015. The overall age-standardized prevalence of amyloidosis increased between 2006 and 2015, especially in individuals aged 45-64 and older than 65 years.
本研究旨在评估 2006 年至 2015 年期间韩国淀粉样变性的患病率。
从 2006 年至 2015 年，从韩国国家健康保险服务中收集了与淀粉样变性相关的主要诊断（无论亚型如何）。
总体而言，2006 年，每 100,000 人中有 0.93（95%置信区间[CI] 0.81, 1.04）人患有淀粉样变性，2015 年每 100,000 人中有 1.91（95%CI 1.78, 2.05）人。这包括男性从每 100,000 人中有 0.43（95%CI 0.35, 0.51）人增加到 1.04（95%CI 0.94, 1.14）人，女性从每 100,000 人中有 0.49（95%CI 0.40, 0.57）人增加到 0.87（95%CI 0.77, 0.96）人。特别是，2006 年至 2015 年，65 岁及以上患者和 45-64 岁患者的淀粉样变性标准化患病率增幅大于 20-44 岁患者，无论男女。
2015 年，淀粉样变性的总体标准化患病率约为每 100,000 人 2 人。2006 年至 2015 年间，淀粉样变性的总体标准化患病率有所增加，尤其是在 45-64 岁和 65 岁以上人群中。
