D'Andrea Mark A, Reddy G Kesava
University Cancer and Diagnostic Centers,Houston,Texas.
Disaster Med Public Health Prep. 2018 Apr;12(2):232-240. doi: 10.1017/dmp.2017.59. Epub 2017 Sep 7.
The objective of this study was to assess the adverse health symptoms experienced by adult subjects who were exposed to benzene after a flaring disaster at the BP refinery in Texas City, Texas.
A total of 2162 adults aged 18 years or older and exposed to benzene were included. Using the patients' medical charts, we collected and analyzed data on health complaints as well as the patients' serum levels of beta-2-microglobulin and urinary excretion of phenol.
A total of 11,368 health symptom complaints were reported in 2162 adults exposed to benzene. Neurological symptoms occurred most frequently (174%), followed upper respiratory symptoms (115%), cough (31%), painful joints (30%), cardiac symptoms (28%), dermatological symptoms (28%), gastrointestinal symptoms (27%), diarrhea (25%), vision symptoms (21%), and nausea/vomiting (19%). Logistic regression analysis indicated that urinary symptoms (R2=0.65) and painful joints (R2=0.44) were positively associated with increasing age in benzene-exposed subjects.
Adult subjects exposed to benzene experience a range of adverse health symptoms and an altered profile of urinary phenol, thus indicating they are at high risk of developing serious future health complications. (Disaster Med Public Health Preparedness. 2018;12:232-240).
本研究的目的是评估在得克萨斯州得克萨斯城英国石油公司炼油厂发生火炬事故后接触苯的成年受试者所经历的不良健康症状。
共纳入2162名18岁及以上且接触苯的成年人。利用患者的病历，我们收集并分析了关于健康投诉以及患者血清β-2-微球蛋白水平和尿酚排泄的数据。
在2162名接触苯的成年人中，共报告了11368例健康症状投诉。神经症状出现频率最高（174%），其次是上呼吸道症状（115%）、咳嗽（31%）、关节疼痛（30%）、心脏症状（28%）、皮肤症状（28%）、胃肠道症状（27%）、腹泻（25%）、视力症状（21%）和恶心/呕吐（19%）。逻辑回归分析表明，在接触苯的受试者中，泌尿症状（R2 = 0.65）和关节疼痛（R2 = 0.44）与年龄增长呈正相关。
接触苯的成年受试者经历了一系列不良健康症状，尿酚谱也发生了改变，因此表明他们未来发生严重健康并发症的风险很高。（《灾害医学与公共卫生防范》。2018；12：232 - 240）
