D'Andrea Mark A, Reddy G Kesava
University Cancer and Diagnostic Centers, Houston, USA.
Int J Occup Med Environ Health. 2017 Oct 6;30(6):849-860. doi: 10.13075/ijomeh.1896.00985. Epub 2017 Sep 27.
To evaluate the health effects of benzene exposure among smoking subjects from a prolonged flaring incident that occurred at the British Petroleum (BP) refinery in Texas City, USA.
The study included smoking subjects who had been exposed and unexposed to the benzene release. Using medical charts, clinical data including white blood cell (WBC) counts, platelet counts, hemoglobin, hematocrit, blood urea nitrogen (BUN), creatinine, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the case of smoking subjects exposed to benzene was reviewed and analyzed.
A total of 791 tobacco smoking subjects (benzene-exposed: N = 733, unexposed: N = 58) were included. Benzene-exposed subjects had significantly higher levels of WBC (×103/μl) counts (8±2.1 vs. 7.5±1.6, p = 0.003) and platelet (×103/μl) counts (263.7±69.7 vs. 222.9±44.3, p = 0.000) as compared with the unexposed subjects. The mean hemoglobin, hematocrit, BUN, and creatinine levels did not differ significantly between the benzene-exposed and -unexposed smoking subjects. Serum levels of ALP (IU/l) was significantly elevated in the benzene-exposed subjects compared with the unexposed subjects (84.5±16.9 vs. 73.8±15.9, p = 0.002). Similarly, benzene-exposed subjects had significantly higher levels of AST and ALT as compared with those unexposed subjects.
Despite a smoking history, residents exposed to benzene from the prolonged BP flaring incident experienced significant alterations in hematological and hepatic functions indicating their vulnerability to the risk of developing hepatic or blood related disorders. Int J Occup Med Environ Health 2017;30(6):849-860.
评估美国德克萨斯城英国石油公司（BP）炼油厂发生的长期火炬燃烧事件中，吸烟人群接触苯对健康的影响。
该研究纳入了接触和未接触苯泄漏的吸烟人群。通过查阅病历，对接触苯的吸烟人群的临床数据进行了回顾和分析，这些数据包括白细胞（WBC）计数、血小板计数、血红蛋白、血细胞比容、血尿素氮（BUN）、肌酐、碱性磷酸酶（ALP）、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）。
共纳入791名吸烟人群（接触苯组：N = 733，未接触苯组：N = 58）。与未接触苯的人群相比，接触苯的人群白细胞（×10³/μl）计数（8±2.1对7.5±1.6，p = 0.003）和血小板（×10³/μl）计数（263.7±69.7对222.9±44.3，p = 0.000）显著更高。接触苯和未接触苯的吸烟人群的平均血红蛋白、血细胞比容、BUN和肌酐水平无显著差异。与未接触苯的人群相比，接触苯的人群血清ALP（IU/l）水平显著升高（84.5±16.9对73.8±15.9，p = 0.002）。同样，与未接触苯的人群相比，接触苯的人群AST和ALT水平显著更高。
尽管有吸烟史，但长期接触BP火炬燃烧事件中苯的居民血液和肝脏功能出现了显著改变，表明他们易患肝脏或血液相关疾病。《国际职业医学与环境卫生杂志》2017年；30(6):849 - 860。
