D'Andrea Mark A, Reddy G Kesava
University Cancer and Diagnostic Centers, 12811 Beamer Road, Houston 77089, TX, USA.
Environ Health. 2014 Dec 20;13:115. doi: 10.1186/1476-069X-13-115.
Human exposure to benzene is associated with multiple adverse health effects with an increased risk of developing carcinogenesis. Benzene exposure is known to affect many critical organs including the hematological, hepatic, renal, lung, and cardiac functions. The purpose of this study is to examine the health effects of benzene exposure among nonsmoking subjects from a prolonged flaring incident that occurred at the British petroleum (BP) refinery in the Texas City, Texas.
The study included nonsmoking subjects who had been exposed and unexposed to benzene. Using medical charts, clinical data including white blood cell (WBC) counts, platelet counts, hemoglobin, hematocrit, blood urea nitrogen (BUN), creatinine, alkaline phosphatase (ALP), aspartate amino transferase (AST), and alanine amino transferase (ALT) in nonsmoking subjects exposed to benzene were reviewed and analyzed and compared with unexposed adults.
A total of 1422 nonsmoking subjects (benzene exposed, n=1093 and unexposed, n=329) were included. Benzene exposed subjects had significantly higher levels of WBC (×10(3) per μL) counts (7.7±2.2 versus 6.8±1.7, P=0.001) and platelet (×10(3) per μL) counts (288.8±59.0 versus 245.3±54.4, P=0.001) compared with the unexposed subjects. The mean serum creatinine (mg/dL) levels were also significantly increased in the benzene exposed group compared with the unexposed group (1.1±0.4 versus 0.8±0.2, P=0.001). Serum levels of ALP (IU/L) was significantly elevated in the benzene exposed subjects compared with the unexposed subjects (87.3±22.6 versus 69.6±16.5, P=0.001). Similarly, benzene exposed subjects had significantly higher levels of AST and ALT compared with those unexposed subjects.
Benzene exposure from the prolonged BP flaring incident caused significant alterations in hematological and liver markers indicating that these nonsmoking residents exposed to refinery chemicals may be at a higher risk of developing hepatic or blood related disorders.
人体接触苯会导致多种不良健康影响，并增加患癌风险。已知苯暴露会影响许多重要器官，包括血液、肝脏、肾脏、肺和心脏功能。本研究的目的是调查得克萨斯州得克萨斯城英国石油公司（BP）炼油厂长期火炬燃烧事件中，非吸烟受试者接触苯对健康的影响。
该研究纳入了接触过苯和未接触过苯的非吸烟受试者。通过查阅病历，对接触苯的非吸烟受试者的临床数据进行回顾分析，这些数据包括白细胞（WBC）计数、血小板计数、血红蛋白、血细胞比容、血尿素氮（BUN）、肌酐、碱性磷酸酶（ALP）、天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT），并与未接触苯的成年人进行比较。
总共纳入了1422名非吸烟受试者（接触苯组，n = 1093；未接触苯组，n = 329）。与未接触苯的受试者相比，接触苯的受试者白细胞计数（每微升×10³）显著更高（7.7±2.2对6.8±1.7，P = 0.001），血小板计数（每微升×10³）也显著更高（288.8±59.0对245.3±54.4，P = 0.001）。与未接触苯组相比，接触苯组的血清肌酐平均水平（mg/dL）也显著升高（1.1±0.4对0.8±0.2，P = 0.001）。与未接触苯的受试者相比，接触苯的受试者血清碱性磷酸酶水平（IU/L）显著升高（87.3±22.6对69.6±16.5，P = 0.001）。同样，接触苯的受试者天冬氨酸氨基转移酶和丙氨酸氨基转移酶水平也显著高于未接触苯的受试者。
BP炼油厂长期火炬燃烧事件导致的苯暴露引起血液和肝脏指标的显著变化，表明这些接触炼油厂化学品的非吸烟居民可能有更高的患肝脏或血液相关疾病的风险。
