Donati Aline, Gupta Aditya K, Jacob Carolina, Cavelier-Balloy Benedicte, Reygagne Pascal
Department of Dermatology, University of São Paulo, São Paulo, Brazil.
Department of Dermatology, Hospital do Servidor Publico Municipal de São Paulo, São Paulo, Brazil.
Skin Appendage Disord. 2017 Aug;3(3):125-128. doi: 10.1159/000469665. Epub 2017 Apr 1.
Frontal fibrosing alopecia (FFA) differs from lichen planopilaris (LPP) in many clinical aspects, but histology fails to distinguish between these entities. Direct immunofluorescence (DIF) is a diagnostic technique used for autoimmune diseases, including those affecting skin and hair.
To characterize DIF patterns in patients with FFA.
Data was collected retrospectively from FFA cases presenting to the Centre de Santé Sabouraud Hair Clinic in Paris from November 2013 to November 2014.
Of 149 patients with FFA, 44 cases underwent DIF. Thirteen cases showed positive results with DIF. Patterns characteristic of LPP and lupus erythematosus were observed, with nearly half showing nonspecific staining.
DIF patterns in patients with FFA were variable. This diagnostic technique should be used with caution in cases of cicatricial alopecia, particularly FFA.
额部纤维性秃发（FFA）在许多临床方面与扁平苔藓性秃发（LPP）不同，但组织学无法区分这些实体。直接免疫荧光（DIF）是一种用于自身免疫性疾病的诊断技术，包括那些影响皮肤和毛发的疾病。
描述FFA患者的DIF模式。
回顾性收集2013年11月至2014年11月在巴黎萨布罗健康毛发诊所就诊的FFA病例的数据。
在149例FFA患者中，44例接受了DIF检查。13例DIF结果呈阳性。观察到LPP和红斑狼疮的特征性模式，近一半显示非特异性染色。
FFA患者的DIF模式是可变的。在瘢痕性秃发病例中，尤其是FFA，应谨慎使用这种诊断技术。
