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在牙科治疗期间通过黏膜下途径镇静来管理自闭症患者的行为。

Managing the behavior of a patient with autism by sedation via submucosal route during dental treatment.

作者信息

Jo Chan-Woo, Park Chan-Hee, Lee Jong-Hyug, Kim Ji-Hun

机构信息

Department of Pediatric Dentistry, Wonju Severance Christian Hospital, Yonsei University, Wonju, Korea.

Department of Dentistry, Wonju College of Medicine, Yonsei University, Wonju, Korea.

出版信息

J Dent Anesth Pain Med. 2017 Jun;17(2):157-161. doi: 10.17245/jdapm.2017.17.2.157. Epub 2017 Jun 29.

DOI:10.17245/jdapm.2017.17.2.157
PMID:28879345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5564151/
Abstract

In sedation via the submucosal route, the drug is administered through the maxillary buccal submucosa. It is time saving, effective, and safe. Patients with autism, a mental disorder, often find it hard to make relationships with other people. These patients display a strong resistance to dental treatment and sedation. This study reports a successful case of behavioral management during dental treatment, using sedation via the submucosal route. The patient was strongly resistant to sedation via the oral, intramuscular, and intravenous routes. The drug used was 9 mg (0.1 mg/kg) of midazolam. Through this case report, we reaffirm the significance of sedation via the submucosal route, and expect that it will be used more frequently for patients with autism, who display behaviors that are difficult to manage, patients with other disabilities, and children.

摘要

在通过黏膜下途径进行镇静时,药物通过上颌颊侧黏膜下给药。这种方法省时、有效且安全。患有自闭症(一种精神障碍)的患者通常很难与他人建立关系。这些患者对牙科治疗和镇静表现出强烈的抗拒。本研究报告了一例在牙科治疗期间通过黏膜下途径进行镇静的行为管理成功案例。该患者对口服、肌肉注射和静脉注射镇静均有强烈抗拒。使用的药物是9毫克(0.1毫克/千克)咪达唑仑。通过本病例报告,我们重申了黏膜下途径镇静的重要性,并期望它能更频繁地用于患有难以管理行为的自闭症患者、其他残疾患者和儿童。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d083/5564151/8536d44d15a3/jdapm-17-157-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d083/5564151/8536d44d15a3/jdapm-17-157-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d083/5564151/8536d44d15a3/jdapm-17-157-g001.jpg

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本文引用的文献

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J Dent Anesth Pain Med. 2015 Jun;15(2):47-52. doi: 10.17245/jdapm.2015.15.2.47. Epub 2015 Jun 30.
2
Efficacy and safety of midazolam for sedation in pediatric dentistry: a controlled clinical trial.咪达唑仑用于儿童牙科镇静的疗效与安全性:一项对照临床试验。
J Dent Child (Chic). 2013 Sep-Dec;80(3):133-8.
3
Autism: definition, neurobiology, screening, diagnosis.
自闭症:定义、神经生物学、筛查与诊断
Pediatr Clin North Am. 2008 Oct;55(5):1129-46, viii. doi: 10.1016/j.pcl.2008.07.005.
4
Comparison of the effectiveness of oral diazepam and midazolam for the sedation of autistic patients during dental treatment.口服地西泮和咪达唑仑在牙科治疗期间对自闭症患者镇静效果的比较。
Pediatr Dent. 2005 May-Jun;27(3):198-206.
5
Effect of submucosal midazolam on behavior and physiologic response when combined with oral chloral hydrate and nitrous oxide sedation.黏膜下注射咪达唑仑与口服水合氯醛及氧化亚氮镇静联合使用时对行为和生理反应的影响。
Pediatr Dent. 2004 Jan-Feb;26(1):37-43.
6
Comparison of the effect of orally versus submucosally administered meperidine on the behavior of pediatric dental patients: a retrospective study.口服与黏膜下注射哌替啶对儿童牙科患者行为影响的比较:一项回顾性研究。
Anesth Prog. 2003;50(3):129-33.
7
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8
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Clin Pharmacol Ther. 1996 May;59(5):491-502. doi: 10.1016/S0009-9236(96)90177-0.
10
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Pediatr Dent. 1994 May-Jun;16(3):190-2.