口腔咪达唑仑喷雾剂作为儿科牙科清醒镇静鼻内途径的替代方法。
Buccal midazolam spray as an alternative to intranasal route for conscious sedation in pediatric dentistry.
作者信息
Chopra Radhika, Mittal Meenu, Bansal Kalpana, Chaudhuri Payal
出版信息
J Clin Pediatr Dent. 2013 Winter;38(2):171-3. doi: 10.17796/jcpd.38.2.n055763721297702.
OBJECTIVES
To evaluate the acceptance of midazolam spray through buccal route as compared to intranasal route and compare the efficacy of the drug through both the routes.
STUDY DESIGN
30 patients aged 2-8 years with Grade I or II Frankl's Behaviour Rating Scale were selected who required similar treatment under local anesthesia on two teeth. Midazolam spray was administered randomly through buccal or intranasal routes for the two appointments. Scoring was done for the acceptance of drug and Houpt's score was recorded for the behaviour of patients during the treatment.
RESULTS
Acceptance of drug through buccal route was significantly better than the intranasal route (p < 0.05) but no statistically significant difference was found in the behaviour scores for the two routes of administration (p > 0.05).
CONCLUSION
Midazolam spray can be effectively used through the buccal mucosa in children who give poor compliance with the intranasal administration.
目的
评估与鼻内途径相比，咪达唑仑口腔喷雾途径的接受度，并比较该药物通过两种途径的疗效。
研究设计
选取30名年龄在2至8岁、Frankl行为评级量表为I级或II级的患者，他们需要在局部麻醉下对两颗牙齿进行类似治疗。在两次就诊时，随机通过口腔或鼻内途径给予咪达唑仑喷雾。对药物接受度进行评分，并记录患者在治疗期间的Houpt评分。
结果
药物通过口腔途径的接受度显著优于鼻内途径（p < 0.05），但两种给药途径的行为评分未发现统计学上的显著差异（p > 0.05）。
结论
对于鼻内给药依从性差的儿童，咪达唑仑喷雾可通过口腔黏膜有效使用。
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