De Paepe Boel, Lefever Steve, Mestdagh Pieter
Laboratory for Mitochondrial Investigations & Neuromuscular Reference Center, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
Center for Medical Genetics, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.
Curr Genet. 2018 Feb;64(1):163-172. doi: 10.1007/s00294-017-0744-1. Epub 2017 Sep 6.
The cellular transcriptome contains a wide diversity of untranslated RNAs, of which the class of regulatory long noncoding RNAs (lncRNAs) has only recently been recognized. Evidence swiftly accumulates of lncRNAs influencing mitochondrial activities of eukaryotic cells, and perturbed expression is conspicuously associated with human diseases. In this review, we describe the multifaceted effects of lncRNAs on mitochondrial function, more particularly on the balance between oxidative phosphorylation and glycolysis, on the production of reactive oxygen species, and on apoptosis in human cells. Emphasis is placed on the involvement of lncRNAs in cancer metabolism, as tumor cells rely heavily on modifications of mitochondrial functioning as an essential component for sustained tumorigenesis and cancer progression. From the nonexhaustive list of lncRNAS described in this review, ANRIL, AScmtRNA, H19, HOTAIR, LincRNA-p21, MALAT1, RMRP, SAMMSON, and VL30 have emerged as potent regulators of mitochondrial metabolism. Due to their key role in cancer progression, they represent potential targets of innovative lncRNA-based treatment strategies.
细胞转录组包含各种各样的非编码RNA，其中调控性长链非编码RNA（lncRNA）这一类直到最近才被认识到。lncRNA影响真核细胞线粒体活动的证据迅速积累，其表达紊乱与人类疾病显著相关。在本综述中，我们描述了lncRNA对线粒体功能的多方面影响，特别是对氧化磷酸化与糖酵解之间的平衡、活性氧的产生以及人类细胞凋亡的影响。重点关注lncRNA在癌症代谢中的作用，因为肿瘤细胞严重依赖线粒体功能的改变作为持续肿瘤发生和癌症进展的重要组成部分。从本综述中所描述的lncRNA的非详尽列表来看，ANRIL、AScmtRNA、H19、HOTAIR、LincRNA-p21、MALAT1、RMRP、SAMMSON和VL30已成为线粒体代谢的有效调节因子。由于它们在癌症进展中的关键作用，它们代表了基于lncRNA的创新治疗策略的潜在靶点。
