Cancer Center, The First Hospital of Jilin University, Changchun, 130021, China; VA Palo Alto Health Care System and Stanford University Medical School, Palo Alto, CA 94304, USA.
Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, R3Y 0G1, Canada.
Crit Rev Oncol Hematol. 2018 Nov;131:76-82. doi: 10.1016/j.critrevonc.2018.08.005. Epub 2018 Aug 27.
LncRNAs, as new players in the old battle against cancer, are significant components of gene regulatory networks. Mitochondria-associated lncRNAs have newly been discovered to work in concert with transcription factors and epigenetic regulators to modulate mitochondrial gene expression and mitochondrial function. Many mitochondria-associated lncRNAs regulate mitochondrial biosynthesis, bioenergetics, apoptosis and possibly govern the cross-talk of mitochondria with nuclei. The complexity of mitochondria-associated lncRNAs is now just starting to envisage. In this review, we collected available evidence that reinforces the importance of mitochondria-associated lncRNA in cancer metabolism, apoptosis, and cell senescence. For the non-exhaustive list of mitochondria-associated lncRNAs, we identified 18 lncRNAs in total (mitochondria-encoded lncRNAs or nuclei encoded mitochondria function associated lncRNAs) as emerging new players in cancer mitochondrial function. As lncRNAs exhibit cancer-type-specific expression patterns, they are attractive targets for selective therapeutic interventions. Manipulation of their function may thus represent a valuable strategy for future cancer treatment.
长链非编码 RNA（lncRNAs）作为在与癌症的这场“旧”战斗中的新角色，是基因调控网络的重要组成部分。新发现线粒体相关 lncRNAs 与转录因子和表观遗传调节剂协同作用，调节线粒体基因表达和线粒体功能。许多线粒体相关 lncRNAs 调节线粒体生物合成、生物能量、细胞凋亡，并可能控制线粒体与细胞核的相互作用。线粒体相关 lncRNAs 的复杂性现在才刚刚开始显现。在这篇综述中，我们收集了现有证据，强调了线粒体相关 lncRNA 在癌症代谢、细胞凋亡和细胞衰老中的重要性。对于非详尽的线粒体相关 lncRNAs 列表，我们总共确定了 18 个 lncRNAs（线粒体编码 lncRNAs 或细胞核编码与线粒体功能相关的 lncRNAs）作为癌症线粒体功能的新兴新角色。由于 lncRNAs 表现出癌症类型特异性的表达模式，因此它们是选择性治疗干预的有吸引力的靶标。因此，对其功能的操纵可能代表未来癌症治疗的一种有价值的策略。
