Nagarathnam M, Shalini B, Vijayalakshmi V, Vengamma B, Latheef S A A
Department of Medical and Surgical Nursing, College of Nursing, Tirupati, Andhra Pradesh, India.
Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Neurol India. 2017 Sep-Oct;65(5):1019-1024. doi: 10.4103/neuroindia.NI_1251_15.
Assessment of quality of life (QOL) reveals the impact of diseases and factors responsible for the impairment of quality of life. The purpose of this study was to evaluate the QOL among adolescents with epilepsy (AWE) in the state of Andhra Pradesh.
One hundred and fifty AWE aged 13-19 years were evaluated for QOL using the Telugu version of the Quality of Life in Epilepsy Inventory for Adolescents (QOLIE) AD-48 and the data were analyzed to predict the factors responsible for determining the QOL.
The mean age of AWE was 15.86 ± 2.14 years. The age at onset of seizures among AWE was 9.28 ± 4.90 years. Generalized (45%) and partial seizures (34%) were the predominant types of seizures. The majority of AWE (77%) were taking anti epileptic medication for 1-8 years, were on monotherapy (55%), and were seizure free for the last 1 year (56%). The mean total QOL score in AWE was 72 ± 15. The high school-educated, seizure-free, and monotherapy-taking AWEs showed a significantly higher mean total QOL when compared to the primary school- educated, seizure-frequent, and polytherapy-taking AWEs (P < 0.01). Education (standardized beta [Sβ] = 0.163 P < 0.05), seizure frequency (Sβ-0.603; P < 0.01), and poly therapy (Sβ-0.08; P < 0.01) were significant predictors of QOL in AWE.
The results of the study suggest that in addition to seizure control, encouraging monotherapy and enhancing the education level may improve the QOL in AWE.
生活质量（QOL）评估揭示了疾病以及导致生活质量受损的因素的影响。本研究的目的是评估安得拉邦青少年癫痫患者（AWE）的生活质量。
使用青少年癫痫患者生活质量量表（QOLIE）AD - 48的泰卢固语版本对150名年龄在13 - 19岁的AWE进行生活质量评估，并对数据进行分析以预测决定生活质量的因素。
AWE的平均年龄为15.86±2.14岁。AWE癫痫发作的起始年龄为9.28±4.90岁。全身性发作（45%）和部分性发作（34%）是主要的发作类型。大多数AWE（77%）服用抗癫痫药物1 - 8年，采用单一疗法（55%），且在过去1年无癫痫发作（56%）。AWE的平均总生活质量得分为72±15。与小学学历、癫痫发作频繁且采用联合治疗的AWE相比，高中学历、无癫痫发作且采用单一疗法的AWE的平均总生活质量得分显著更高（P < 0.01）。教育程度（标准化β系数[Sβ]=0.163；P < 0.05）、癫痫发作频率（Sβ=-0.603；P < 0.01）和联合治疗（Sβ=-0.08；P < 0.01）是AWE生活质量的显著预测因素。
研究结果表明，除了控制癫痫发作外，鼓励单一疗法和提高教育水平可能会改善AWE的生活质量。
