School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074, China.
Plant Protection and Quarantine Station of Dehong, Dehong 678400, China.
Org Lett. 2017 Oct 6;19(19):5201-5203. doi: 10.1021/acs.orglett.7b02559. Epub 2017 Sep 7.
Nicotabin A (1), a sesquiterpenoid derivative possessing a fused 5/6/5/5/5 ring system, was isolated from leaves of Nicotiana tabacum. The structure was elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction. The plausible biosynthetic pathway for 1 was proposed. Compound 1 inhibited nitric oxide production in LPS-activated RAW264.7 macrophages with an IC of 22.1 μM.
尼古丁 A（1），一种具有稠合的 5/6/5/5/5 环系的倍半萜衍生物，从烟草叶片中分离得到。通过广泛的光谱方法阐明了其结构，并通过单晶 X 射线衍射证实。提出了 1 的可能生物合成途径。化合物 1 对 LPS 激活的 RAW264.7 巨噬细胞中的一氧化氮生成具有抑制作用，IC 为 22.1 μM。
