Sun Cheng-Peng, Kutateladze Andrei G, Zhao Feng, Chen Li-Xia, Qiu Feng
Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, USA.
Org Biomol Chem. 2017 Feb 1;15(5):1110-1114. doi: 10.1039/c6ob02656g.
A novel withanolide, aromaphysalin A (1), possessing an exceptional C(11)-C(15) bond and an unprecedented 4,9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound 1 exhibited inhibitory activity on NO production with an IC value of 51.64 μM. A plausible biosynthetic pathway for 1 is also discussed.
从酸浆的茎和叶中分离出一种新型的维A醇类化合物——芳香酸苦素A（1），它具有特殊的C(11)-C(15)键和前所未有的4,9-环化芳香环（A环）。其结构通过高分辨电喷雾电离质谱（HRESIMS）、二维核磁共振谱（2D NMR）以及理论计算确定。化合物1对一氧化氮（NO）的产生具有抑制活性，半数抑制浓度（IC）值为51.64 μM。同时还讨论了化合物1可能的生物合成途径。
