Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Tethnology, Wuhan 430033, China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
J Asian Nat Prod Res. 2022 Sep;24(9):877-883. doi: 10.1080/10286020.2021.1981872. Epub 2021 Oct 14.
A new megastimane sesquiterpenoid, cassianol A (), and five known analogues () were isolated from the leaves extract of Their structures were elucidated by extensive spectroscopic methods and single-crystal X-ray diffraction analyses. All the isolates were isolated from for the first time. The anti-inflammatory activities of compounds were evaluated against nitric oxide (NO) production in LPS-induced RAW 264.7 mouse macrophages.
从 叶片提取物中分离得到了一个新的巨型倍半萜类化合物 cassianol A ()，以及五个已知类似物 ()。通过广泛的光谱方法和单晶 X 射线衍射分析确定了它们的结构。所有分离物均为首次从 中分离得到。对化合物进行了抗炎活性评价，以检测其对 LPS 诱导的 RAW 264.7 小鼠巨噬细胞中一氧化氮 (NO) 生成的抑制作用。
