Lees G J
Neurosci Lett. 1987 Jul 22;78(2):180-6. doi: 10.1016/0304-3940(87)90630-6.
Systemic injections of ketamine (30 mg/kg, i.p.) decreased the neurotoxicity of the NMDA agonists NMDA (N-methyl-D-aspartic acid) and quinolinic acid injected into the hippocampus of the rat, although such protection was incomplete. Simultaneous injections of ketamine into the hippocampus decreased rather than increased these protective effects. In contrast, almost complete protection was provided by intra-hippocampal injections of DL-2-amino-5-phosphonovaleric acid (DL-APV). The duration of anaesthesia was not responsible for the protective effects of systemic ketamine, as the intracerebral injections of the NMDA agonists produced similar neuronal lesions under both halothane or nembutal anaesthesia.
腹腔注射氯胺酮（30毫克/千克）可降低注入大鼠海马体的N-甲基-D-天冬氨酸（NMDA）和喹啉酸等NMDA激动剂的神经毒性，尽管这种保护并不完全。同时向海马体注射氯胺酮会降低而非增强这些保护作用。相比之下，海马体内注射DL-2-氨基-5-磷酸戊酸（DL-APV）可提供几乎完全的保护。全身注射氯胺酮的保护作用与麻醉持续时间无关，因为在氟烷或戊巴比妥麻醉下，脑内注射NMDA激动剂都会产生类似的神经元损伤。
