喹啉酸及相关化合物在体内释放[3H]嘌呤。
In vivo release of [3H]-purines by quinolinic acid and related compounds.
作者信息
Perkins M N, Stone T W
出版信息
Br J Pharmacol. 1983 Oct;80(2):263-7. doi: 10.1111/j.1476-5381.1983.tb10029.x.
Abstract
In vivo release of [3H]-purines from the cortex of anaesthetized rats was measured and the actions of excitatory amino acids and analogues investigated. High KCl, N-methyl-DL-aspartate (NMDLA) and quinolinic acid produced a large increase in basal release of labelled materials. Glutamate, quisqualate and kainate had less effect. The N-methyl-D-aspartic acid (NMDA)-preferring receptor antagonist, 2-amino-7-phosphonohepatanoic acid, significantly reduced the release evoked by NMDLA and quinolinate but not that produced by the other agonists. Kynurenic acid, a compound metabolically related to quinolinic acid, reduced the release due to NMDLA and quinolinate but not glutamate. The results add further support to the suggestion that quinolinic acid acts on the NMDA-preferring receptor.
摘要
测定了麻醉大鼠皮层中[3H]嘌呤的体内释放情况，并研究了兴奋性氨基酸及其类似物的作用。高钾、N-甲基-DL-天冬氨酸（NMDLA）和喹啉酸使标记物质的基础释放大幅增加。谷氨酸、quisqualate和 kainate的作用较小。N-甲基-D-天冬氨酸（NMDA）偏好性受体拮抗剂2-氨基-7-膦酰基庚酸显著降低了NMDLA和喹啉酸盐诱发的释放，但不影响其他激动剂产生的释放。犬尿喹啉酸是一种与喹啉酸代谢相关的化合物，它降低了NMDLA和喹啉酸盐引起的释放，但不影响谷氨酸引起的释放。这些结果进一步支持了喹啉酸作用于NMDA偏好性受体的观点。
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