Caleri D, Marabini S, Panconesi A, Pietrini U
Ric Clin Lab. 1987 Apr-Jun;17(2):155-62.
Vasodilation, conjunctival and nasal edema as well as miosis are symptoms associated with cluster headache (CH) attacks. Similar symptomatology is caused by substance P (SP) release from peripheral trigeminal nerve endings. The symptomatic effect of somatostatin (SRIF) during CH attacks was attributed to the inhibition of SP release from trigeminal neurons. This study was designed to evaluate both the vascular effect of SRIF on the dorsal hand vein and SRIF plasma levels prior to and after subcutaneous and intranasal administration in CH patients. A powerful venoconstriction and tachyphylaxis were demonstrated when SRIF was administered both as bolus and infusion. Plasma levels of SRIF in CH sufferers were lower than in control subjects. Subcutaneous and intranasal SRIF administrations induced maximal plasma levels after 5 and 10 min, respectively. These data suggest that SRIF plays an important role during CH attacks; however, its exact mechanism of action is still to be defined.
血管舒张、结膜和鼻黏膜水肿以及瞳孔缩小是丛集性头痛（CH）发作的相关症状。从外周三叉神经末梢释放的P物质（SP）会引发类似的症状。生长抑素（SRIF）在CH发作期间的症状缓解作用归因于其对三叉神经元释放SP的抑制。本研究旨在评估CH患者皮下和鼻内给药前后，SRIF对手背静脉的血管效应以及SRIF的血浆水平。当以推注和输注方式给药时，SRIF均表现出强烈的静脉收缩和快速耐受性。CH患者的SRIF血浆水平低于对照组。皮下和鼻内给予SRIF分别在5分钟和10分钟后诱导出最大血浆水平。这些数据表明，SRIF在CH发作期间起重要作用；然而，其确切作用机制仍有待确定。
