Sicuteri F, Geppetti P, Marabini S, Lembeck F
Department of Internal Medicine and Clinical Pharmacology, University of Florence, Viale Morgagni 85, 50134 FlorenceItaly Department of Experimental and Clinical Pharmacology, University of Graz, Universitätsplatz 4, A-8010 GrazAustria.
Pain. 1984 Apr;18(4):359-365. doi: 10.1016/0304-3959(84)90048-4.
The pain relieving effect of somatostatin treatment during 72 attacks of cluster headache in 8 male patients was compared to treatment with ergotamine or placebo in a double-blind study. Infusion of somatostatin (25 micrograms/min for 20 min i.v.) reduced the maximal pain intensity and the duration of pain significantly compared to placebo treatment, and to a degree comparable to ergotamine tartrate treatment (250 micrograms i.m.). The results obtained provide new information concerning the possible mechanism of cluster headache attacks and suggest a new therapeutic approach.
在一项双盲研究中，将8名男性患者72次丛集性头痛发作时生长抑素治疗的止痛效果与麦角胺或安慰剂治疗进行了比较。与安慰剂治疗相比，静脉输注生长抑素（25微克/分钟，持续20分钟）显著降低了最大疼痛强度和疼痛持续时间，且降低程度与酒石酸麦角胺治疗（肌肉注射250微克）相当。所得结果为丛集性头痛发作的可能机制提供了新信息，并提出了一种新的治疗方法。
