Roberts Christopher Michael, Lowe Derek, Skipper Emma, Steiner Michael C, Jones Rupert, Gelder Colin, Hurst John R, Lowrey Gillian E, Thompson Catherine, Stone Robert A
Barts Health, Queen Mary University of London, London, UK.
Clinical Effectiveness and Evaluation Unit, Royal College of Physicians of London, London, UK.
BMJ Open. 2017 Sep 6;7(9):e015532. doi: 10.1136/bmjopen-2016-015532.
To evaluate if observed increased weekend mortality was associated with poorer quality of care for patients admitted to hospital with chronic obstructive pulmonary disease (COPD) exacerbation.
Prospective case ascertainment cohort study.
199 acute hospitals in England and Wales, UK.
Consecutive COPD admissions, excluding subsequent readmissions, from 1 February to 30 April 2014 of whom 13 414 cases were entered into the study.
Process of care mapped to the National Institute for Health and Care Excellence clinical quality standards, access to specialist respiratory teams and facilities, mortality and length of stay, related to time and day of the week of admission.
Mortality was higher for weekend admissions (unadjusted OR 1.20, 95% CI 1.00 to 1.43), and for case-mix adjusted weekend mortality when calculated for admissions Friday morning through to Monday night (adjusted OR 1.19, 95% CI 1.00 to 1.43). Median time to death was 6 days. Some clinical processes were poorer on Mondays and during normal working hours but not weekends or out of hours. Specialist respiratory care was less available and less prompt for Friday and Saturday admissions. Admission to a specialist ward or high dependency unit was less likely on a Saturday or Sunday.
Increased mortality observed in weekend admissions is not easily explained by deficiencies in early clinical guideline care. Further study of out-of-hospital factors, specialty care and deaths later in the admission are required if effective interventions are to be made to reduce variation by day of the week of admission.
评估观察到的周末死亡率增加是否与慢性阻塞性肺疾病(COPD)急性加重入院患者的护理质量较差有关。
前瞻性病例确定队列研究。
英国英格兰和威尔士的199家急症医院。
2014年2月1日至4月30日连续的慢性阻塞性肺疾病入院病例,不包括随后的再次入院病例,其中13414例进入研究。
根据英国国家卫生与临床优化研究所临床质量标准绘制护理流程,获得专科呼吸团队和设施的情况,死亡率和住院时间,与入院时间和星期几相关。
周末入院患者的死亡率更高(未调整的比值比为1.20,95%置信区间为1.00至1.43),对于周五上午至周一晚上入院病例进行病例组合调整后的周末死亡率(调整后的比值比为1.19,95%置信区间为1.00至1.43)。死亡的中位时间为6天。一些临床流程在周一和正常工作时间较差,但在周末或非工作时间并非如此。周五和周六入院时,专科呼吸护理的可及性较低且不够及时。周六或周日入住专科病房或高依赖病房的可能性较小。
周末入院患者死亡率增加并非早期临床指南护理不足所能轻易解释的。如果要采取有效干预措施以减少因入院星期几造成的差异,需要进一步研究院外因素、专科护理以及入院后期的死亡情况。