Genkel Vadim, Zaripova Yana, Kuznetsova Alla, Sluchanko Alena, Minasova Anna, Zotova Maria, Saenko Anna, Savochkina Albina, Dolgushina Anastasiya
Department of Internal Medicine, South-Ural State Medical University, Chelyabinsk 454141, Russia.
Department of Hospital Therapy, South-Ural State Medical University, Chelyabinsk 454141, Russia.
Cells. 2025 May 18;14(10):738. doi: 10.3390/cells14100738.
Inflammatory bowel disease (IBD) is a growing global problem, particularly in regions with low sociodemographic indices and growing populations. IBD incidence is increasing among children and adolescents, leading to a growing economic burden. The prevalence of atherosclerotic cardiovascular diseases among patients with IBD is also higher than in the general population. While mortality rates have decreased, cardiovascular disease (CVD) remains a significant contributor to mortality and disability in IBD patients. According to the current understanding, neutrophils play an important role in both the atherogenesis and pathogenesis of IBD. This review addresses the state of the art of neutrophil involvement in the development of atherosclerosis and IBD. In the present review, we summarize the currently available evidence regarding neutrophils as a possible key driver of extraintestinal manifestations of IBD and cardiovascular complications. We provide a discussion on the potential role of neutrophil-derived markers in the development of new approaches for the precise diagnosis of atherosclerosis in patients with IBD, as well as new therapeutic targets.
炎症性肠病（IBD）是一个日益严重的全球性问题，在社会人口统计学指标较低且人口不断增长的地区尤为突出。IBD在儿童和青少年中的发病率正在上升，导致经济负担日益加重。IBD患者中动脉粥样硬化性心血管疾病的患病率也高于普通人群。虽然死亡率有所下降，但心血管疾病（CVD）仍然是IBD患者死亡和残疾的重要原因。根据目前的认识，中性粒细胞在IBD的动脉粥样硬化形成和发病机制中都起着重要作用。本综述阐述了中性粒细胞参与动脉粥样硬化和IBD发展的最新情况。在本综述中，我们总结了目前关于中性粒细胞作为IBD肠外表现和心血管并发症可能的关键驱动因素的现有证据。我们讨论了中性粒细胞衍生标志物在开发IBD患者动脉粥样硬化精确诊断新方法以及新治疗靶点方面的潜在作用。
