Promsuban Charkriya, Limsuvan Suveerawan, Akarasereenont Pravit, Tilokskulchai Kanokwan, Tapechum Sompol, Pakaprot Narawut
aDepartment of Physiology bCenter of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Neuroreport. 2017 Nov 8;28(16):1031-1035. doi: 10.1097/WNR.0000000000000862.
Bacopa monnieri has been used in Ayurvedic medicine as a memory enhancer for a long time; however, its direct effect on synaptic plasticity has not been investigated. To the best of our knowledge, this study is the first to report the effect of B. monnieri on long-term synaptic potentiation in acute hippocampal slices. Adult male Wistar rats were orally administered either sterile water or the ethanolic extract of B. monnieri for 60 days. The extracellular recording was performed to measure the field excitatory postsynaptic potential in the acute hippocampal slices of these rats. Our results showed that B. monnieri extract significantly increased long-term potentiation magnitude compared with the control group, whereas there was no change in basal synaptic transmission. The data support the beneficial mnemonic effect of B. monnieri, and suggest that this effect might be because of the increase of learning-associated synaptic machinery, resulting in the long-term potentiation enhancement and strengthening of hippocampal synapses, which plays a critical role in learning and memory formation.
长期以来，假马齿苋一直被用于阿育吠陀医学中作为记忆增强剂；然而，其对突触可塑性的直接影响尚未得到研究。据我们所知，本研究首次报道了假马齿苋对急性海马切片中长期突触增强的影响。成年雄性Wistar大鼠口服无菌水或假马齿苋乙醇提取物，持续60天。进行细胞外记录以测量这些大鼠急性海马切片中的场兴奋性突触后电位。我们的结果表明，与对照组相比，假马齿苋提取物显著增加了长期增强幅度，而基础突触传递没有变化。这些数据支持了假马齿苋的有益记忆作用，并表明这种作用可能是由于与学习相关的突触机制增加，导致海马突触的长期增强增强和强化，而海马突触在学习和记忆形成中起着关键作用。
