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性别特异性与抑郁相关的疾病模块。

Sex-specific disease-associated modules for depression.

机构信息

Departments of Psychiatry and Neuroscience, Yale University School of Medicine, New Haven, Connecticut, United States.

出版信息

Nat Med. 2017 Sep 8;23(9):1015-1017. doi: 10.1038/nm.4391.

DOI:10.1038/nm.4391
PMID:28886002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5813287/
Abstract

A recent study reveals sexually dimorphic disease-associated gene-expression modules and hub genes in postmortem brains from female and male individuals with depression. These modules are conserved in mouse models of depression.

摘要

最近的一项研究揭示了在患有抑郁症的女性和男性死后大脑中存在性别二态性疾病相关的基因表达模块和枢纽基因。这些模块在抑郁症的小鼠模型中是保守的。

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本文引用的文献

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Sex-specific transcriptional signatures in human depression.人类抑郁症中的性别特异性转录特征。
Nat Med. 2017 Sep;23(9):1102-1111. doi: 10.1038/nm.4386. Epub 2017 Aug 21.
2
Network propagation: a universal amplifier of genetic associations.网络传播:遗传关联的通用放大器。
Nat Rev Genet. 2017 Sep;18(9):551-562. doi: 10.1038/nrg.2017.38. Epub 2017 Jun 12.
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The chronic mild stress (CMS) model of depression: History, evaluation and usage.抑郁症的慢性轻度应激(CMS)模型:历史、评估与应用。
Neurobiol Stress. 2016 Aug 24;6:78-93. doi: 10.1016/j.ynstr.2016.08.002. eCollection 2017 Feb.
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Major depressive disorder.重度抑郁症。
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Reproductive Steroid Regulation of Mood and Behavior.生殖类固醇对情绪和行为的调节
Compr Physiol. 2016 Jun 13;6(3):1135-60. doi: 10.1002/cphy.c150014.
6
Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress.伏隔核转录组图谱中的性别差异与对亚慢性可变应激的易感性和恢复力相关。
J Neurosci. 2015 Dec 16;35(50):16362-76. doi: 10.1523/JNEUROSCI.1392-15.2015.
7
Modules, networks and systems medicine for understanding disease and aiding diagnosis.模块、网络和系统医学,用于理解疾病和辅助诊断。
Genome Med. 2014 Oct 17;6(10):82. doi: 10.1186/s13073-014-0082-6. eCollection 2014.
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Sex differences in stress-related psychiatric disorders: neurobiological perspectives.应激相关精神障碍中的性别差异:神经生物学视角
Front Neuroendocrinol. 2014 Aug;35(3):303-19. doi: 10.1016/j.yfrne.2014.03.008. Epub 2014 Apr 12.
9
Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.按国家、性别、年龄和年份划分的抑郁障碍负担:来自 2010 年全球疾病负担研究的发现。
PLoS Med. 2013 Nov;10(11):e1001547. doi: 10.1371/journal.pmed.1001547. Epub 2013 Nov 5.
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The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species.遗传性别在跨物种的 GABA 相关基因的情绪调节和表达中的作用。
Front Psychiatry. 2013 Sep 17;4:104. doi: 10.3389/fpsyt.2013.00104. eCollection 2013.