Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands; Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.
Am J Geriatr Psychiatry. 2017 Dec;25(12):1339-1348. doi: 10.1016/j.jagp.2017.08.002. Epub 2017 Aug 10.
Although many nursing home residents with dementia show agitation, hardly any literature is published about very frequent agitation. The WAALBED-III study focuses on the 2-week prevalence and correlates of very frequent agitation in these residents.
Cross-sectional study using combined data of four studies.
One hundred nineteen dementia special care units in twenty-six nursing homes in The Netherlands.
Two thousand seventy-four residents with dementia.
We operationally defined very frequent agitation as having a score of 6 (several times a day) or 7 (several times an hour) on at least five items of the Cohen Mansfield Agitation Inventory (CMAI) combined with a CMAI total score above the 90th percentile. To assess the association of demographic and behavioral characteristics with very frequent agitation, we performed a multivariate multilevel logistic regression analysis.
The 2-week prevalence of very frequent agitation was 7.4% (95% CI: 6.374-8.634). Correlates for very frequent agitation were age (OR: 0.967, 95% CI: 0.942-0.992), dementia severity (GDS 6 = OR: 3.636, 95% CI: 1.929-6.875; GDS 7 = OR: 2.951, 95% CI: 1.321-6.588), delusions (OR: 2.480, 95% CI: 1.555-3.956), anxiety (OR: 1.904, 95% CI: 1.259-2.881), euphoria (OR: 3.712, 95% CI: 2.171-6.337) and irritability (OR: 4.411, 95% CI: 2.854-6.816).
To our knowledge, this study is the first to report prevalence data and correlates about nursing home residents with very frequent agitation. We found several correlated factors for very frequent agitation. Still, further research is needed for a better understanding of the behavior of this group, and to identify good treatment options.
尽管许多患有痴呆症的养老院居民表现出躁动,但几乎没有任何文献报道过非常频繁的躁动。WAALBED-III 研究专注于这些居民非常频繁躁动的两周患病率和相关因素。
使用四项研究的综合数据进行横断面研究。
荷兰 26 家养老院的 119 个痴呆症特殊护理病房。
2074 名患有痴呆症的居民。
我们将非常频繁的躁动定义为 Cohen-Mansfield 躁动量表(CMAI)的至少五项项目得分为 6(每天几次)或 7(每小时几次),并且 CMAI 总分高于第 90 百分位数。为了评估人口统计学和行为特征与非常频繁躁动的关联,我们进行了多变量多级逻辑回归分析。
非常频繁躁动的两周患病率为 7.4%(95%CI:6.374-8.634)。非常频繁躁动的相关因素包括年龄(OR:0.967,95%CI:0.942-0.992)、痴呆严重程度(GDS 6=OR:3.636,95%CI:1.929-6.875;GDS 7=OR:2.951,95%CI:1.321-6.588)、妄想(OR:2.480,95%CI:1.555-3.956)、焦虑(OR:1.904,95%CI:1.259-2.881)、欣快(OR:3.712,95%CI:2.171-6.337)和易怒(OR:4.411,95%CI:2.854-6.816)。
据我们所知,这项研究是第一个报告关于养老院居民非常频繁躁动的患病率数据和相关因素的研究。我们发现了一些与非常频繁躁动相关的因素。尽管如此,为了更好地了解这一群体的行为,并确定良好的治疗选择,仍需要进一步的研究。