Hadziselimović F, Huff D, Duckett J, Herzog B, Elder J, Snyder H, Buser M
University Children's Hospital, Basel, Switzerland.
J Urol. 1987 Oct;138(4 Pt 2):1043-5. doi: 10.1016/s0022-5347(17)43495-1.
We studied 48 prepubertal boys with cryptorchidism between 1 year 3 months and 11 years old who were treated with buserelin every other day for 6 months. Urinary luteinizing and follicle-stimulating hormones, and testosterone remained unchanged during the entire treatment period. In boys older than 7 years a slight but significant increase in testosterone was noted in the first morning voided urine at the end of treatment. Testicular biopsies were obtained at orchiopexy in all patients in whom testicular descent was not complete (83 per cent). A significant increase in the number of germ cells was observed in patients with unilateral and those with bilateral cryptorchidism, indicating that 6 months of buserelin therapy improved the fertility status even when testes were in an undescended position during treatment.
我们研究了48名1岁3个月至11岁的青春期前隐睾男孩，他们每隔一天接受布舍瑞林治疗6个月。在整个治疗期间，尿促黄体生成素、促卵泡生成素和睾酮水平保持不变。在7岁以上的男孩中，治疗结束时首次晨尿中的睾酮有轻微但显著的升高。所有睾丸未完全下降的患者（83%）在睾丸固定术中均进行了睾丸活检。单侧和双侧隐睾患者的生殖细胞数量均显著增加，这表明即使在治疗期间睾丸处于未降位置，6个月的布舍瑞林治疗仍改善了生育状况。
